West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (6): 624-632.doi: 10.7518/hxkq.2021.06.002

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Research progress on the application of framework nucleic acid in bone regeneration

Lin Yunfeng()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-04-20 Revised:2021-09-17 Online:2021-12-01 Published:2021-12-03
  • Contact: Lin Yunfeng E-mail:yunfenglin@scu.edu.cn
  • Supported by:
    National Key R&D Program of China(2019YFA0110600);National Natural Science Foundation of China(81970916)


Framework nucleic acid (FNA) is a set of DNA nanostructures characterized by the framework morphology. It can design rational DNA sequences and follow the principle of complementary base pairing to construct FNA. The recent discovery of FNA constructed by DNA nanotechnology has great application potential in the field of bone regene-ration. It plays a positive role in the osteogenic differentiation of stem cells, bone regeneration, vascular regeneration, neuromodulation, immune regulation, and drug delivery. Here, we reviewed the current study findings on FNA in the field of bone regeneration.

Key words: framework nucleic acid, DNA nanostructure, bone regeneration, tissue engineering

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