West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (3): 324-329.doi: 10.7518/hxkq.2020.03.017

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Research progress on the biological regulatory function of lysophosphatidic acid in bone tissue cells

Wu Xiangnan1,2, Ma Yuanyuan2, Hao Zhichao2, Wang Hang1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.Hospital of Stomatology, Sun Yat-sen University, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2019-05-21 Revised:2019-12-19 Online:2020-06-01 Published:2020-05-28
  • Contact: Hang Wang E-mail:wanghang@scu.edu.cn
  • Supported by:
    Sichuan Science and Technology Program(2019YFH0153);Guangdong Basic and Applied Basic Research Foundation(2019A1515110810)


Lysophosphatidic acid (LPA) is a small phospholipid that is present in all eukaryotic tissues and blood plasma. As an extracellular signaling molecule, LPA mediates many cellular functions by binding to six known G protein-coupled receptors and activating their downstream signaling pathways. These functions indicate that LPA may play important roles in many biological processes that include organismal development, wound healing, and carcinogenesis. Recently, many studies have found that LPA has various biological effects in different kinds of bone cells. These findings suggest that LPA is a potent regulator of bone development and remodeling and holds promising application potential in bone tissue engineering. Here, we review the recent progress on the biological regulatory function of LPA in bone tissue cells.

Key words: lysophosphatidic acid, osteoblast, osteoclast, osteocyte, bone tissue engineering

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