West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (4): 441-446.doi: 10.7518/hxkq.2018.04.016

• Orginal Article • Previous Articles     Next Articles

Research progress on chitosan composite scaffolds in bone tissue engineering

Xinxin Ding1(), Yanmin Zhou1(), Xing-chen Xiang1, Lin Meng2, Qin Qin1, Shan Ye1   

  1. 1. Dept. of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
    2. Dept. of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2017-06-30 Revised:2018-05-16 Online:2018-08-01 Published:2018-08-01
  • Supported by:
    The National Natural Science Foundation of China (81570983);High Technology Industrial Development (2014G075)


Bone tissue engineering is a scientific field devoted to the development of materials that can repair or replace human bone tissue with biological and engineering methods. The stent, which provides structural support and adhesion sites for cell and tissue growth, is one of the key elements in tissue engineering. The scaffold may comprise metal, polymer, and ceramic biomaterial. The polymer scaffold is widely used due to its biocompatibility, biodegradability, and mechanical stability. Chitosan, as a natural polymer, is derived from chitin and has played a particularly important role in bone tissue engineering over the past two decades. In recent years, chitosan composites and their application in bone tissue engineering have received considerable attention due to their small foreign body reaction, excellent antibacterial properties, plasticity, suitability for inward cell growth, and bone conduction. This review will discuss the biocompatibility and osteogenesis research in vivo and in vitro of several common chitosan composites in bone tissue engineering.

Key words: bone tissue engineering, chitosan, scaffold, bone regeneration, osteoblast

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