West China Journal of Stomatology ›› 2019, Vol. 37 ›› Issue (4): 398-402.doi: 10.7518/hxkq.2019.04.011

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Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone

Tiantian Yu1,2,3,Jin Liu1,4,Junjing Yin1,2,5,Xiangna Xu1,2,Shengjie Yan1,2,Jing Lan1,2()   

  1. 1.Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
    2.Dept. of Implantology, School & Hospital of Stomatology, Shandong University, Jinan 250012, China
    3.Dept. of Implantology, Yantai Stomatology Hospital, Yantai 264008, China
    4.Dept. of Prosthodontics, School & Hospital of Stomatology, Shandong University, Jinan 250012, China
    5.Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China
  • Received:2019-02-27 Revised:2019-05-25 Online:2019-08-01 Published:2019-08-23
  • Contact: Jing Lan E-mail:kqlj@sdu.edu.cn
  • Supported by:
    Natural Science Foundation of Shandong Province(ZR2015HM065)


Objective To explore the effect of concentrated growth factors (CGF) on postoperative pain and swelling in patients with complex dental implants. Methods A total of 28 patients with single maxillary anterior teeth loss and labial orbital bone defect were recruited randomly and divided into two groups. Each group included 14 patients. The experimental group was applied with CGF membrane to guide bone regeneration, whereas the control group was treated with collagen membrane to guide bone regeneration. The postoperative pain degree and swelling degree were compared, and data were analyzed with SPSS 23.0 software. Postoperative pain was measured by visual analogue scale (VAS), and the degree of swelling was divided into four grades according to swelling range. Results VAS scores of patients in experimental and control groups reached 35.1±22.5 and 47.0±20.3, respectively. The duration of postoperative pain in experimental and control groups totaled (2.1±1.5) and (2.8±1.0) days, respectively. No statistically significant difference was observed between the two groups (P>0.05). Percentages of non-swelling, mild swelling, moderate swelling, and severe swelling in experimental group reached 21.4%, 57.1%, 21.4%, and 0, respectively, and those in control group were 7.1%, 35.7%, 35.7%, and 21.4%. Swelling duration reached (2.4±1.4) and (4.2±2.2) days in the experimental and control groups, respectively. A statistically significant difference was observed in the swelling degree of experimental and control groups (P<0.05). Conclusion The use of CGF can significantly reduce the degree of postoperative swelling and shorten swelling time but cause no significant effect on pain.

Key words: concentrated growth factors, guided bone regeneration, postoperative reaction

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