West China Journal of Stomatology ›› 2012, Vol. 30 ›› Issue (5): 487-492.doi: 10.3969/j.issn.1000-1182.2012.05.009

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Low intensity pulsed ultrasound irradiating combined with guided bone regeneration for promoting the repair effect of periodontal bone defect

Jiang Xinyi1, Yang Ji2, Chai Zhaowu3, Song Jinlin1, Deng Feng1, Wang Zhibiao4.   

  1. 1. Dept. of Orthodontics, The Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Research Center for Oral Diseases and Biomedical Science, Chongqing 401147, China; 2. Dept. of Stomatology, Tongliang County People’s Hospital of Chongqing, Chongqing 402560, China; 3. Dept. of Stomatology, Chongqing Three Gorges Central Hospital, Chongqing 404000, China; 4. Chongqing Key Laboratory of Ultrasound Medical Engineering Cofounded
    by Chongqing and Ministry of Science and Technology, Chongqing 400016, China)
  • Received:2011-12-12 Revised:2012-02-20 Online:2012-10-01 Published:2012-10-01


Objective To study the repair effect of low intensity pulsed ultrasound(LIPUS) irradiating combined with guided bone regeneration(GBR) on the defect of Beagle dog canines periodontal bone. Methods Four canine teeth of every beagle dog(8 beagle dogs) were randomly distributed: Group 1(LIPUS disposal + GBR+ autogenous bone graft group), group 2(LIPUS disposal + autogenous bone graft group), group 3(GBR + autogenous bone graft group), blank control group. The model of periodontal bone defect was established in the 1/3 part of the root buccal area. According to the group division, autogenous bone were grafted, group 1 and group 2 were disposed by LIPUS 20 min·d-1. The intensity of ultrasound were 30 mW·cm-2. Group 1 and group 3 were injected with Bio-Gide collagen membrane. The beagle dogs were executed at 6 and 8 weeks of the disposal of LIPUS and then Micro-CT test and analysis were conducted to periodontal bone defect area of each group. Results By clinical observation, there were different degrees of shrinkages of the area of periodontal bone defect in each group. The Micro-CT test analysis indicated that there was a statistical difference among the number, the thickness as well as the size of bone trabecula of each group
(P <0.05). However, there was no statistical difference (P >0.05) in terms of bone issue measurement index between 6 to 8 weeks of each group. Group 1 had the most new bone. Conclusion LIPUS has the potential to promote the repair of periodontal bone defect. Therefore the combination of LIPUS and GBR may be more conducive to the repair and regeneration of periodontal bone defect.

Key words: low intensity pulsed ultrasound, guided bone regeneration, bone defect, repair effect