West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (3): 319-323.doi: 10.7518/hxkq.2020.03.016

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Research progress on the regulation of phenolic compounds of traditional Chinese herbs on oral microbes

Zong Yawen, Cheng Lei, Guo Qiang, Zhou Xuedong, Ren Biao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-04-21 Revised:2019-10-19 Online:2020-06-01 Published:2020-05-28
  • Contact: Biao Ren E-mail:renbiao@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81600858)


Phenolic compounds are widely found in natural Chinese medicinal plants and have excellent pharmacological properties, such as antioxidation and anti-inflammation. They are the main pharmacological components of many medicinal Chinese herbs. Oral microbiota, especially its composition and metabolism, is highly related to the balance of oral microecology and plays a key role in the occurrence and development of oral diseases. Recent studies have shown that phenolic compounds of traditional Chinese herbs can prevent and treat oral diseases, such as caries, periodontal disease, and oral mucosal infection, by regulating the composition, metabolites, and virulence of oral microorganisms. This review will summarize and discuss the regulation of phenolic compounds on oral microbes.

Key words: traditional Chinese herbs, phenolic compounds, oral microbes, pathogenic virulence

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