West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (2): 221-226.doi: 10.7518/hxkq.2021.02.015

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Advances in molecular mechanisms of bone invasion by oral cancer

Liu Wei(), Li Chunjie(), Li Longjiang   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-17 Revised:2020-12-19 Online:2021-04-01 Published:2021-04-09
  • Contact: Li Chunjie E-mail:liuwei-scu@qq.com;lichunjie@scu.edu.cn
  • Supported by:
    Scientific Research Project of Sichuan Health and Family Planning Commission(18PJ094);Sichuan University Luzhou People,s Government Strategic Cooperation Project(2018CDLZ-12)


Bone invasion by oral cancer is a common clinical problem, which affects the choice of treatment and predicts a poor prognosis. Unfortunately, the molecular mechanism of this phenomenon has not been fully elucidated. Current studies have revealed that oral cancer cells modulate the formation and function of osteoclasts through the expression of a series of signal molecules. Many signal pathways are involved in this process, of which receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB/osteoprotegerin signaling pathway attracted much attention. In this review, we introduce recent progress in molecular mechanisms of bone invasion by oral cancer.

Key words: oral cancer, bone invasion, molecular mechanism, osteoclast

CLC Number: