West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (1): 59-68.doi: 10.7518/hxkq.2020.01.011

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Effect of the local application of stem cells on repairing facial nerve defects: a systematic review

Zhao Dan,Li Yueheng,Yang Zhengyan,Cai Ting,Wu Xiaoyan,Xia Yu,Zhou Zhi()   

  1. Dept. of Preventive Stomatology, Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401120, China
  • Received:2019-06-21 Revised:2019-09-19 Online:2020-02-01 Published:2020-02-06
  • Contact: Zhi Zhou E-mail:500119@hospital.cqmu.edu.cn
  • Supported by:
    Program for Innovation Team Building at Institutions of Higher Education in Chongqing(CXTDG201602006)


Objective To systematically evaluate the repairing effect of stem cells on facial nerve defects. Methods Articles regarding the regenerating effect of stem cells on facial nerves in animals were collected from the databases of Pubmed, Cochrane Library, Web of Science, Embase, Scopus, and CBM. Two professionals independently completed the article screening, data extraction, and bias risk assessment. RevMan 5.3 and random-effects models were used for the statistical analysis, and the results were presented in the form of mean differences (MD) with a 95%CI. The results of functional evaluation (vibrissae movement, facial paralysis) and histological evaluation (density of myelinated fibers, diameter of fibers, thickness of myelin sheath, G ratio) of facial nerve were Meta-analyzed. Results A total of 4 614 articles were retrieved from the 6 databases, and 15 of these articles were included in the Meta-analysis. For vibrissae movement and facial paralysis, the stem cell group scored significantly higher than the non-stem cell group (P<0.05). The density of myelinated fibers and thickness of the myelin sheath in the stem cell group were higher than those in the non-stem cell group (P<0.05). The G ratio in the stem cell group was smaller than that in the non-stem cell group (P=0.001). There was no significant difference in fiber diameter (P=0.08). Conclusion Stem cells have potential in promoting facial nerve regeneration.

Key words: stem cell, facial nerve, neural tissue engineering, systematic review

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