West China Journal of Stomatology ›› 2022, Vol. 40 ›› Issue (1): 1-6.doi: 10.7518/hxkq.2022.01.001

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Progress and perspectives on cell-free regenerative endodontic therapy

Zhou Jian1,2,3(), Su Yingying3,4, Wang Song-ling1,3,5()   

  1. 1.Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China
    2.Dept. of VIP Dental Service, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
    3.Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
    4.Dept. of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
    5.School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2021-06-16 Revised:2021-12-10 Online:2022-02-01 Published:2022-02-07
  • Contact: Wang Song-ling E-mail:zhoujian@ccmu.edu.cn;slwang@ccmu.edu.cn
  • Supported by:
    Chinese Research Unit of Tooth Development and Regeneration, CAMS Innovation Fund for Medical Scien-ces(2019-12M-5-031);Beijing Municipal Administration of Hospitals’ Mission Plan(SML20151401);Beijing Municipal Education Commission(119207020201);Beijing Municipality Government Grants (Beijing Scholar Program) (PXM2020_014226_000005,PXM2019_014226_000039,PXM2019_014226_000011,PXM2018_014226_000021,PXM-2017_014226_000023, PXM2018_193312_000006_0028S643_FCG, PXM2016_014226_000034);National Natural Sci-ence Foundation of China(91649124);Beijing Natural Science Foundation(7222079);Correspondence: Wang Songling, E-mail: slwang@ccmu.edu.cn


Although teeth with pulpitis/apical periodontitis are saved after successful endodontic therapy, they are devitalized and susceptible to reinfections and fractures. The development of biology-based approaches for dental pulp regeneration or repair is possible today because of recent advances in tissue engineering and biomaterials. Cell-free regenerative endodontic therapy offers a promising strategy for the treatment of necrotic immature permanent teeth in children and adolescents. However, studies are underway to determine whether this procedure can be applied to mature teeth.

Key words: cell-free regenerative endodontic therapy, cell homing, stem cell, tissue engineering

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