West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (3): 330-337.doi: 10.7518/hxkq.2020.03.018

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Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Wen Jiahui, Wu Yanmin(), Chen Lili   

  1. Dept. of Periodontology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2019-02-21 Revised:2019-12-19 Online:2020-06-01 Published:2020-05-28
  • Contact: Yanmin Wu E-mail:wuyanmin@zju.edu.cn
  • Supported by:
    Zhejiang Basic Public Welfare Research Program(LGF18H140003)


Human periodontal ligament-derived cells serve as an important source of seeding cells in periodontal regenerative medicine, and their osteogenic potential is closely related to alveolar bone repair and periodontal regeneration. Non-coding RNA (ncRNA), such as microRNA, long non-coding RNA, and circular RNA, play important roles in the regulation of osteogenic genes in human periodontal ligament-derived cells. In this review, we summarize the target genes, pathways, and functions of the ncRNA network during osteogenic differentiation of periodontal ligament-derived cells.

Key words: microRNA, long non-coding RNA, circular RNA, periodontal ligament cell, periodontal ligament stem cell, osteogenic differentiation

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