West China Journal of Stomatology ›› 2022, Vol. 40 ›› Issue (1): 7-13.doi: 10.7518/hxkq.2022.01.002

Previous Articles     Next Articles

Prospect on the application of mesenchymal stem cell-derived extracellular vesicles in the regeneration of dental and maxillofacial tissues

Liao Li(), Tian Weidong.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine & Dept. of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-11-26 Revised:2021-11-05 Online:2022-02-01 Published:2022-02-07
  • Contact: Tian Weidong. E-mail:lliao@scu.edu.cn;drtwd@sina.com
  • Supported by:
    The National Natural Science Foundation of China(82071092);Key Project of Sichuan Province(2019YFS0311);Correspondence: Tian Weidong, E-mail: drtwd@sina.com


Extracellular vesicles (EVs) are the essential mediators of communication between different cells or tissues. EVs participate in the development, homeostasis, repair, and regeneration of tissues. Mesenchymal stem cells(MSCs) secrete a range of bioactive factors, which are important in MSC-mediated tissue regeneration. Great progress has been made in the research of EVs derived from MSCs (MSC-EVs) in the regeneration of dental and maxillofacial tissues. Emerging evidence confirmed that MSC-EVs can efficiently modulate the proliferation, differentiation, survival, and migration of stem or progenitor cells and stimulate the regeneration of the neurovascular system. MSC-EVs have been used in regenerating dental pulp, periodontium, jawbone, temporomandibular joint, and maxillofacial soft tissues. Having the advantages of low immunogenicity, versatile function, and suitability for large-scale production, EVs have excellent clinical application prospect. Along with investigations on molecular mechanisms of action and development of standard manufactory and testing systems, therapies u-sing MSC-EVs are promising strategies for regenerating dental and maxillofacial tissues.

Key words: extracellular vesicles, mesenchymal stem cells, tooth, jawbone, regeneration

CLC Number: