牙本质基质在组织再生中的应用

doi:10.7518/hxkq.2019.01.018

摘要/Abstract

摘要：

组织器官病变严重影响到人们的生活质量,组织器官缺损可能威胁人们的生命,组织、器官缺损的修复和功能重建是现代医学面临的挑战。组织工程为再生组织器官带来希望。组织工程支架为细胞的生长、增殖和分化提供了微环境,而且影响着形成组织的大小和形态。牙本质基质作为一种天然的生物活性支架,具有良好的生物相容性,在组织工程中得到广泛的应用,成为研究热点。学者们以牙本质基质为支架,开展了包括牙根、牙周、牙髓、骨等软硬组织缺损修复的研究,取得了一系列重要进展。本文对牙本质生物学特性、牙本质基质在组织再生中的应用等进行综述,为临床应用牙本质基质进行组织再生提供参考。

关键词: 牙本质基质, 组织工程, 牙再生, 骨再生

Abstract:

Lesions on tissues and organs critically affect quality of life, due to severe tissue defects that are threatening. Tissue repair and functional reconstruction are concurrent challenges in modern medicine. Tissue engineering brings hope for tissue and organ regeneration. Scaffolds provide a microenvironment for cell growth, proliferation and differentiation. Moreover, scaffolds influence the size and morphology of regenerated tissues. Dentin matrix, which is a natural bioactive and biocompatible scaffold, has become a research hotspot in recent years and has been widely used in tissue engineering. Studies on the use of dentin matrix as scaffolds have made a series of important progress in tooth root, periodontal, dental pulp and bone regeneration. This review demonstrates the biological characteristics of dentin matrix as bioactive scaffolds, describes the application of dentin matrix in tissue regeneration and provides a theoretical basis for the use of a dentin matrix in clinical applications.

Key words: dentin matrix, tissue engineering, tooth regeneration, bone regeneration

中图分类号:

Q 78

朱甜,郭维华. 牙本质基质在组织再生中的应用[J]. 华西口腔医学杂志, 2019, 37(1): 92-96.

Tian Zhu,Weihua. Guo. Dentin matrix in tissue regeneration: a progress report[J]. West China Journal of Stomatology, 2019, 37(1): 92-96.

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