吸烟对慢性牙周炎牙龈微循环影响的初步研究

doi:10.7518/hxkq.2019.05.006

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (5): 485-489.doi: 10.7518/hxkq.2019.05.006

吸烟对慢性牙周炎牙龈微循环影响的初步研究

王旭^1,^2,³,石磊⁴,应绚^1,^2,³,童钰鑫^1,^2,³,张佳喻^1,^2,³,石旭妍^1,^2,³,陈悦^1,^2,³()

1.西安交通大学口腔医学院牙周黏膜科
2.陕西省颅颌面精准医学研究重点实验室
3.陕西省牙颌面疾病临床研究中心,西安 710004
4.青岛市海慈医疗集团,青岛 266000

收稿日期:2019-03-31 修回日期:2019-07-05 出版日期:2019-10-01 发布日期:2019-10-15
通讯作者: 陈悦 E-mail:dentistcy@126.com
作者简介:王旭,硕士,E-mail：1191241149@qq.com
基金资助:
陕西省自然科学基金基础研究计划(2018JM7116)

Preliminary study on the effects of smoking on gingival microcirculation in chronic periodontitis

Wang Xu^1,^2,³,Shi Lei⁴,Ying Xuan^1,^2,³,Tong Yuxin^1,^2,³,Zhang Jiayu^1,^2,³,Shi Xuyan^1,^2,³,Chen Yue^1,^2,³()

1.Dept. of Periodontitis and Mucosal Disease, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
2.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi’an 710004, China
3.Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi’an 710004, China
4.Qingdao Haici Medical Group, Qingdao 266000, China

Received:2019-03-31 Revised:2019-07-05 Online:2019-10-01 Published:2019-10-15
Contact: Yue Chen E-mail:dentistcy@126.com
Supported by:
Natural Science Fund Basic Research Program of Shaanxi Province(2018JM7116)

摘要/Abstract

摘要：

目的从牙龈微循环方面探讨吸烟促进慢性牙周炎的机制。方法试验一选取慢性牙周炎吸烟患者（A组）、慢性牙周炎不吸烟患者（B组）、牙周健康不吸烟志愿者（C组）上前牙各102颗,应用激光多普勒血流仪进行上前牙区牙龈血流量（GBF）检测。试验二根据是否吸烟将牙周翻瓣术中取材牙龈分为吸烟组（A’组）和不吸烟组（B’组）,并将牙周健康不吸烟者行牙冠延长术或埋伏阻生智齿拔除术中取材牙龈作为对照组（C’组）,通过组织切片进行3组牙龈组织微血管密度（MVD）计数。采用SPSS 22.0软件包进行数据统计分析。结果 B组与C组相比,各牙位GBF均有增加,其中12牙、21牙、23牙差异有统计学意义（P<0.05）。B’组MVD高于C’组（P<0.05）;A’组与B’组MVD间差异无统计学意义（P>0.05）。结论牙周炎症会引起GBF、牙龈MVD的增高,但吸烟并不会引起牙龈微循环（GBF、MVD）的显著变化,尚不支持吸烟通过影响牙龈微循环促进慢性牙周炎发生发展这一机制。

关键词: 牙龈血流量, 微血管密度, 慢性牙周炎

Abstract:

Objective To explore the mechanism of smoking that promotes chronic periodontitis from the perspective of gingival microcirculation. Methods In experiment one, upper anterior teeth (n=102) from smokers with chronic periodontitis (Group A), nonsmokers with chronic periodontitis (Group B), and nonsmokers with healthy periodontal conditions (Group C) were selected to undergo gingival blood flow (GBF) through laser doppler flowmetry. In experiment two, the tissues obtained from gums during periodontal flap surgery were divided into smoking (Group A’) and nonsmoking (Group B’) groups, and the gingival tissue obtained from periodontal healthy nonsmokers treated with crown lengthening surgery or impacted wisdom tooth extraction served as the control group (Group C’). The microvessels density (MVD) of the gingival tissue from the three groups was determined in the tissue sections. SPSS 22.0 was used for statistical analysis. Results Compared with group C, GBF of all teeth increased in group B, and there were significant differences among 12, 21 and 23 teeth. MVD significantly differed between Group B’ and C’ (P<0.05), but they did not significantly differ between Group A’ and B’. Conclusion Periodontitis can increase GBF and MVD, but smoking does not cause significant changes. However, the mechanism by which smoking promotes the occurrence and development of chronic periodontitis by influencing gingival microcirculation has not been discussed in this research.

Key words: gingival blood flow, microvessels density, chronic periodontitis

中图分类号:

R781.4

王旭,石磊,应绚,童钰鑫,张佳喻,石旭妍,陈悦. 吸烟对慢性牙周炎牙龈微循环影响的初步研究[J]. 华西口腔医学杂志, 2019, 37(5): 485-489.

Wang Xu,Shi Lei,Ying Xuan,Tong Yuxin,Zhang Jiayu,Shi Xuyan,Chen Yue. Preliminary study on the effects of smoking on gingival microcirculation in chronic periodontitis[J]. West China Journal of Stomatology, 2019, 37(5): 485-489.

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组别	11牙	12牙	13牙	21牙	22牙	23牙
A组	4.33±0.94	4.47±0.61	4.40±0.63	4.80±0.80	4.42±0.74	4.42±0.32
B组	4.50±0.79	4.73±0.55	5.00±0.75	4.92±0.92	5.13±0.80	5.53±1.39
C组	1.75±0.22*	1.73±0.22*	1.43±0.23*	1.51±0.22*	1.69±0.19*	1.73±0.21*

组别	11牙	12牙	13牙	21牙	22牙	23牙
A组	36.03±12.56	38.13±8.07	31.13±11.86	28.57±8.18	29.49±12.12	36.53±14.62
B组	35.59±11.66	42.71±15.18	33.16±17.74	41.63±14.18	30.41±16.55	42.28±15.22
C组	27.73±8.62	29.81±9.42*	27.25±10.46	25.50±8.33*	29.02±9.12	27.40±9.74*

组别	年龄/岁	PD/mm
A’组	36.75±11.24	5.17±1.21
B’组	31.67±5.96	5.53±1.16
C’组	28.17±9.56	2.33±0.19*

吸烟对慢性牙周炎牙龈微循环影响的初步研究

Preliminary study on the effects of smoking on gingival microcirculation in chronic periodontitis

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