组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用

doi:10.7518/hxkq.2019.01.020

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (1): 102-105.doi: 10.7518/hxkq.2019.01.020

组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用

孙晋,刘芸,屈茜,曲娟,罗纬,张锋,吴敏()

南方医科大学附属深圳市妇幼保健院口腔病防治中心,深圳 518048

收稿日期:2018-02-16 修回日期:2018-11-03 出版日期:2019-02-01 发布日期:2019-02-01
通讯作者: 吴敏 E-mail:szwumin1998@126.com
作者简介:孙晋,住院医师,硕士,E-mail：631589163@qq.com
基金资助:
深圳市科创委立项(JCYJ20160427191204874);中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目(20-18FYH013)

Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue

Jin Sun,Yun Liu,Qian Qu,Juan Qu,Wei Luo,Feng Zhang,Min. Wu()

Stomatology Health Care Center, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518048, China

Received:2018-02-16 Revised:2018-11-03 Online:2019-02-01 Published:2019-02-01
Contact: Min. Wu E-mail:szwumin1998@126.com
Supported by:
Shenzhen Science and Technology Innovation Committee(JCYJ20160427191204874);Biostime Maternal and Infant Nutrition and Health Research Project of National Center for Women and Children’s Health, China CDC(20-18FYH013)

摘要/Abstract

摘要：

表观遗传是指基因序列不发生改变的前提下,基因表达却发生改变,且这种改变能够遗传至后代。其中,组蛋白乙酰化属于表观遗传范畴中重要的一种类型。现有的研究表明慢性牙周炎的发生与表观遗传修饰具有一定的关系。结合已有研究,本文对组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用作一综述。

关键词: 组蛋白乙酰化, 慢性牙周炎, 牙周膜干细胞, 成骨分化

Abstract:

Epigenetics is defined as a change in gene expression without the alteration of the genetic sequence. Such a change would be inherited by offspring. Histone acetylation is a type of epigenetics. Existing studies proposed that chronic periodontitis is related to epigenetic modification. In this review, we summarised the influence of chronic periodontitis on periodontal ligament stem cells by histone acetylation.

Key words: histone acetylation, chronic periodontitis, periodontal ligament stem cells, osteogenic differentiation

中图分类号:

Q 786

孙晋,刘芸,屈茜,曲娟,罗纬,张锋,吴敏. 组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用[J]. 华西口腔医学杂志, 2019, 37(1): 102-105.

Jin Sun,Yun Liu,Qian Qu,Juan Qu,Wei Luo,Feng Zhang,Min. Wu. Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue[J]. West China Journal of Stomatology, 2019, 37(1): 102-105.

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组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用

Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue

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