Research progress on circular RNA in oral squamous cell carcinoma

doi:10.7518/hxkq.2020.04.013

Abstract

Abstract:

Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.

Key words: circular RNA, biogenesis of circRNA, biology function, oral squamous cell carcinoma, biomarker

CLC Number:

Lei Kexin, Bai Hetian, Yang Songyue, Li Jing, Chen Qianming. Research progress on circular RNA in oral squamous cell carcinoma[J]. West China Journal of Stomatology, 2020, 38(4): 425-430.

References 51

[1]	Wu H, Yang L, Chen LL. The diversity of long noncoding RNAs and their generation[J]. Trends Genet, 2017,33(8):540-552. URL pmid: 28629949
[2]	Li J, Yang J, Zhou P, et al. Circular RNAs in cancer: novel insights into origins, properties, functions and implications[J]. Am J Cancer Res, 2015,5(2):472-480. URL pmid: 25973291
[3]	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats[J]. RNA, 2013,19(2):141-157. doi: 10.1261/rna.035667.112 URL pmid: 23249747
[4]	Talhouarne GJ, Gall JG. Lariat intronic RNAs in the cytoplasm of Xenopus tropicalis oocytes[J]. RNA, 2014,20(9):1476-1487. URL pmid: 25051970
[5]	Meng X, Li X, Zhang P, et al. Circular RNA: an emerging key player in RNA world[J]. Brief Bioinform, 2017,18(4):547-557. doi: 10.1093/bib/bbw045 URL pmid: 27255916
[6]	Lu Z, Filonov GS, Noto JJ, et al. Metazoan tRNA introns generate stable circular RNAs in vivo[J]. RNA, 2015,21(9):1554-1565. doi: 10.1261/rna.052944.115 URL pmid: 26194134
[7]	Liu J, Liu T, Wang X, et al. Circles reshaping the RNA world: from waste to treasure[J]. Mol Cancer, 2017,16(1):58. doi: 10.1186/s12943-017-0630-y URL pmid: 28279183
[8]	Fitzmaurice C, Dicker D, Pain A, et al. The global burden of cancer 2013[J]. JAMA Oncol, 2015,1(4):505-527.
[9]	Brocklehurst PR, Baker SR, Speight PM. Oral cancer screening: what have we learnt and what is there still to achieve[J]. Future Oncol, 2010,6(2):299-304.
[10]	Demetrick DJ, Inoue M, Lester WM, et al. Human papillomavirus type 16 associated with oral squamous carcinoma in a cardiac transplant recipient[J]. Cancer, 1990,66(8):1726-1731. doi: 10.1002/1097-0142(19901015)66:8<1726::aid-cncr2820660814>3.0.co;2-y URL pmid: 2169995
[11]	Williams HK. Molecular pathogenesis of oral squamous carcinoma[J]. Mol Pathol, 2000,53(4):165-172. URL pmid: 11040937
[12]	Chen LL, Yang L. Regulation of circRNA biogenesis[J]. RNA Biol, 2015,12(4):381-388. URL pmid: 25746834
[13]	Cocquerelle C, Mascrez B, Hétuin D, et al. Mis-splicing yields circular RNA molecules[J]. FASEB J, 1993,7(1):155-160. doi: 10.1096/fasebj.7.1.7678559 URL pmid: 7678559
[14]	Meng S, Zhou H, Feng Z, et al. CircRNA: functions and properties of a novel potential biomarker for cancer[J]. Mol Cancer, 2017,16(1):94. doi: 10.1186/s12943-017-0663-2 URL pmid: 28535767
[15]	Lasda E, Parker R. Circular RNAs: diversity of form and function[J]. RNA, 2014,20(12):1829-1842. doi: 10.1261/rna.047126.114 URL pmid: 25404635
[16]	Zaphiropoulos PG. Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: correlation with exon skipping[J]. Proc Natl Acad Sci U S A, 1996,93(13):6536-6541. doi: 10.1073/pnas.93.13.6536 URL pmid: 8692851
[17]	Salzman J. Circular RNA expression: its potential regulation and function[J]. Trends Genet, 2016,32(5):309-316. doi: 10.1016/j.tig.2016.03.002 URL pmid: 27050930
[18]	Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2[J]. Nucleic Acids Res, 2016,44(6):2846-2858. URL pmid: 26861625
[19]	Du WW, Fang L, Yang W, et al. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity[J]. Cell Death Differ, 2017,24(2):357-370. URL pmid: 27886165
[20]	Chen CY, Sarnow P. Initiation of protein synjournal by the eukaryotic translational apparatus on circular RNAs[J]. Science, 1995,268(5209):415-417. doi: 10.1126/science.7536344 URL pmid: 7536344
[21]	Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine[J]. Cell Res, 2017,27(5):626-641. doi: 10.1038/cr.2017.31 URL pmid: 28281539
[22]	Shang X, Li G, Liu H, et al. Comprehensive circular RNA profiling reveals that hsa_circ_0005075, a new circular RNA biomarker, is involved in hepatocellular crcinoma development[J]. Medicine (Baltimore), 2016,95(22):e3811.
[23]	Yang X, Xiong Q, Wu Y, et al. Quantitative proteomics reveals the regulatory networks of circular RNA CDR1as in hepatocellular carcinoma cells[J]. J Proteome Res, 2017,16(10):3891-3902. doi: 10.1021/acs.jproteome.7b00519 URL pmid: 28892615
[24]	Ren S, Xin Z, Xu Y, et al. Construction and analysis of circular RNA molecular regulatory networks in liver cancer[J]. Cell Cycle, 2017,16(22):2204-2211. doi: 10.1080/15384101.2017.1346754 URL pmid: 28727484
[25]	Pei W, Tao L, Zhang LW, et al. Circular RNA profiles in mouse lung tissue induced by radon[J]. Environ Health Prev Med, 2017,22(1):36. doi: 10.1186/s12199-017-0627-6 URL pmid: 29165116
[26]	Xie H, Ren X, Xin S, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer[J]. Oncotarget, 2016,7(18):26680-26691. doi: 10.18632/oncotarget.8589 URL pmid: 27058418
[27]	Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types[J]. PLoS One, 2012,7(2):e30733. doi: 10.1371/journal.pone.0030733 URL pmid: 22319583
[28]	Li W, Zhong C, Jiao J, et al. Characterization of hsa_circ_0004277 as a new biomarker for acute myeloid leukemia via circular RNA profile and bioinformatics analysis[J]. Int J Mol Sci, 2017,18(3):597.
[29]	Zhang Y, Liu H, Li W, et al. CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630[J]. Aging (Albany NY), 2017,9(6):1585-1594.
[30]	Huang M, He YR, Liang LC, et al. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer[J]. World J Gastroenterol, 2017,23(34):6330-6338. doi: 10.3748/wjg.v23.i34.6330 URL pmid: 28974900
[31]	Chen J, Li Y, Zheng Q, et al. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer[J]. Cancer Lett, 2017,388:208-219. doi: 10.1016/j.canlet.2016.12.006 URL pmid: 27986464
[32]	Liang HF, Zhang XZ, Liu BG, et al. Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271[J]. Am J Cancer Res, 2017,7(7):1566-1576. URL pmid: 28744405
[33]	Lu L, Sun J, Shi P, et al. Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer[J]. Oncotarget, 2017,8(27):44096-44107. doi: 10.18632/oncotarget.17307 URL pmid: 28484086
[34]	Bachmayr-Heyda A, Reiner AT, Auer K, et al. Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues[J]. Sci Rep, 2015,5:8057. doi: 10.1038/srep08057 URL pmid: 25624062
[35]	Zhong Z, Lü M, Chen J. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma[J]. Sci Rep, 2016,6:30919. doi: 10.1038/srep30919 URL pmid: 27484176
[36]	Ahmed I, Karedath T, Andrews SS, et al. Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma[J]. Oncotarget, 2016,7(24):36366-36381. doi: 10.18632/oncotarget.8917 URL pmid: 27119352
[37]	Sand M, Bechara FG, Gambichler T, et al. Circular RNA expression in cutaneous squamous cell carcinoma[J]. J Dermatol Sci, 2016,83(3):210-218. doi: 10.1016/j.jdermsci.2016.05.012 URL pmid: 27298156
[38]	赵思语, 欧阳少波, 王军, 等. 口腔鳞状细胞癌组织中环状RNA的差异表达谱分析[J]. 口腔疾病防治, 2018,26(2):83-89.
	Zhao SY, Ouyang SB, Wang J , et al. Differential expression of circular RNA in oral squamous cell carcinoma[J]. J Dent Prevent Treat, 2018,26(2):83-89.
[39]	邹艾灵, 赵建江, 孙翔, 等. 舌鳞状细胞癌中环状RNA的表达谱特征[J]. 中山大学学报(医学科学版), 2018,39(2):186-191, 219.
	Zhou AL, Zhao JJ, Sun X , et al. Expression profile of circularRNA in tongue squamous cell carcinoma[J]. J Sun Yat-sen Univ (Med Sci), 2018,39(2):186-191, 219.
[40]	Wang K, Liang Q, Wei L, et al. MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor[J]. Tumour Biol, 2016,37(3):3823-3830. doi: 10.1007/s13277-015-4213-5 URL pmid: 26474589
[41]	Chen L, Zhang S, Wu J, et al. circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family[J]. Oncogene, 2017,36(32):4551-4561. URL pmid: 28368401
[42]	Wang L, Wei Y, Yan Y, et al. CircDOCK1 suppresses cell apoptosis via inhibition of miR-196a-5p by targeting BIRC3 in OSCC[J]. Oncol Rep, 2018,39(3):951-966. doi: 10.3892/or.2017.6174 URL pmid: 29286141
[43]	Sun S, Li B, Wang Y, et al. Clinical significance of the decreased expression of hsa_circ_001242 in oral squamous cell carcinoma[J]. Dis Markers, 2018,2018:6514795. doi: 10.1155/2018/6514795 URL pmid: 30069275
[44]	Zhao SY, Wang J, Ouyang SB, et al. Salivary circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as novel biomarkers for the diagnosis of oral squamous cell carcinoma[J]. Cell Physiol Biochem, 2018,47(6):2511-2521. doi: 10.1159/000491624 URL pmid: 29991057
[45]	Dumache R. Early diagnosis of oral squamous cell carcinoma by salivary microRNAs[J]. Clin Lab, 2017,63(11):1771-1776. doi: 10.7754/Clin.Lab.2017.170607 URL pmid: 29226639
[46]	Tang H, Wu Z, Zhang J, et al. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. Mol Med Rep, 2013,7(3):761-766. doi: 10.3892/mmr.2012.1254 URL
[47]	Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs[J]. Nat Biotechnol, 2014,32(5):453-461. doi: 10.1038/nbt.2890 URL
[48]	Chen B, Wei W, Huang X, et al. circEPSTI1 as a prognostic marker and mediator of triple-negative breast cancer progression[J]. Theranostics, 2018,8(14):4003-4015. URL pmid: 30083277
[49]	Song L, Xiao Y. Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway[J]. Biochem Biophys Res Commun, 2018,503(4):2603-2610. doi: 10.1016/j.bbrc.2018.08.007 URL pmid: 30139516
[50]	Wang L, Wei Y, Yan Y, et al. CircDOCK1 suppresses cell apoptosis via inhibition of miR-196a-5p by targeting BIRC3 in OSCC[J]. Oncol Rep, 2018,39(3):951-966. doi: 10.3892/or.2017.6174 URL pmid: 29286141
[51]	Liu X, Abraham JM, Cheng Y, et al. Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation[J]. Mol Ther Nucleic Acids, 2018,13:312-321. doi: 10.1016/j.omtn.2018.09.010 URL pmid: 30326427