West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (4): 425-430.doi: 10.7518/hxkq.2020.04.013

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Research progress on circular RNA in oral squamous cell carcinoma

Lei Kexin1(), Bai Hetian1, Yang Songyue2, Li Jing1(), Chen Qianming1   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. West China Clinical Medicine School, Sichuan University, Chengdu 610041, China
  • Received:2018-10-18 Revised:2020-05-19 Online:2020-08-01 Published:2020-08-03
  • Contact: Li Jing E-mail:lijing1984@scu.edu.com
  • Supported by:
    The National Natural Science Foundation of China(81872211);The National Natural Science Foundation of China(81672675);The National Natural Science Foundation of China(81621062);Discipline Innovation and Wisdom Introduction Program for Institutions of High Learning(B14038);The Young Elite Scientist Sponsorship Program by China Association for Science and Technology(2017QNRC001);The Sichuan University Innovation and Entrepreneurship Training Program for Undergraduates(20171083)


Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.

Key words: circular RNA, biogenesis of circRNA, biology function, oral squamous cell carcinoma, biomarker

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