浓缩生长因子联合黏性骨在上前牙牙槽嵴保存术中的临床效果评价

doi:10.7518/hxkq.2025.2025013

摘要/Abstract

摘要：

目的比较浓缩生长因子（CGF）膜和Bio-Gide^®胶原膜，分别与Bio-Oss^®黏性骨联合用于上前牙牙槽嵴保存术（ARP）的临床效果。方法选取30例上前牙拔除后需要行ARP的患者，随机分为Bio-Gide组和CGF组。2组均在拔牙窝内严密充填Bio-Oss^®黏性骨。Bio-Gide组用Bio-Gide^®胶原膜覆盖于Bio-Oss^®黏性骨上缘并封闭拔牙窝，CGF组用CGF膜覆盖并封闭拔牙窝。对比2组术后10 d软组织愈合情况，术后即刻及6个月牙槽嵴骨宽度及高度变化，以及术后6个月医患满意度。结果术后6个月，2组牙槽嵴骨宽度及高度变化差异无统计学意义（P>0.05）。但CGF组术后软组织愈合情况及医患满意度方面表现更优，差异有统计学意义（P<0.05）。结论与Bio-Gide^®胶原膜相比，CGF膜与Bio-Oss^®黏性骨联合应用可使上前牙ARP术后软组织愈合更好、医患满意度更高。

关键词: 牙槽嵴保存, 黏性骨, 浓缩生长因子, 胶原膜, 种植

Abstract:

Objective To compare the clinical effects of concentrated growth factor (CGF) membrane and Bio-Gide^® collagen membrane, combined with Bio-Oss^® sticky bone respectively in alveolar ridge preservation (ARP) of maxillary anterior teeth. Methods Thirty patients who needed alveolar ridge preservation after maxillary anterior tooth extraction were selected and randomly assigned to the Bio-Gide group and the CGF group. In both groups, the extraction sockets were tightly filled with the Bio-Oss^® sticky bone. In the Bio-Gide group used Bio-Gide^® collagen membrane to cover the upper edge of the Bio-Oss^® sticky bone and closed the wound. The CGF group, the CGF membrane was covered on the upper edge of the Bio-Oss^® sticky bone and the wound was closed. The soft tissue wound healing status at 10 days after ARP, the changes in alveolar ridge height and width immediately after ARP and at 6 months after ARP, and the doctor-patient satisfaction at 6 months after ARP were compared and evaluated between the two groups. Results At 6 months after ARP, there was no statistically significant difference in the changes of alveolar bone width and height between the two groups (P>0.05). However, the CGF group showed better performance in soft tissue healing after ARP and doctor-patient satisfaction, and the differences were statistically significant (P<0.05). Conclusion Compared with the Bio-Gide^® collagen membrane, the combined application of CGF membrane and Bio-Oss^® sticky bone can lead to better soft tissue healing after ARP of maxillary anterior teeth and higher doctor-patient satisfaction, showing obvious advantages in ARP of maxillary anterior teeth.

Key words: alveolar ridge preservation, sticky bone, concentrated growth factor, collagen membrane, implant

中图分类号:

R783.4

魏雪琴, 张盛智, 巴凯. 浓缩生长因子联合黏性骨在上前牙牙槽嵴保存术中的临床效果评价[J]. 华西口腔医学杂志, 2025, 43(5): 671-678.

Wei Xueqin, Zhang Shengzhi, Ba Kai. Evaluation of the clinical effect of concentrated growth factor combined with sticky bone in maxillary anterior alveolar ridge preservation[J]. West China Journal of Stomatology, 2025, 43(5): 671-678.

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组别	W₀	W₁	W_Δ
P值	0.46	0.67	0.31
Bio-Gide组	7.52±1.29	6.17±1.08	1.35±0.63
CGF组	7.81±1.52	6.25±1.49	1.56±0.92

组别	H₀	H₁	H_Δ
P值	0.82	0.98	0.52
Bio-Gide组	18.51±2.17	17.29±1.76	1.22±0.78
CGF组	18.73±1.84	17.46±1.53	1.27±0.69

组别	创面愈合评分				P值
组别	0分	1分	2分	3分	P值
Bio-Gide组	5	7	4	0	0.04
CGF组	8	5	1	0	0.04

组别	患者	医生
P值	0.008	0.031
Bio-Gide组	7（6，8）	8（7，8）
CGF组	9（9，9）	9（8，9）