West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (5): 571-575.doi: 10.7518/hxkq.2020.05.017

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A review of mechanisms by which low-intensity pulsed ultrasound affects bone regeneration

Jiang Yixuan(), Gong Ping, Zhang Liang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-12-07 Revised:2020-06-04 Online:2020-10-01 Published:2020-10-14
  • Contact: Zhang Liang E-mail:531935636@qq.com;liangzhang@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81500895);The National Natural Science Foundation of China(81571008)


Low-intensity pulsed ultrasound (LIPUS) is a common physical therapy to accelerate the healing of bone fracture and treat delayed union of bone fracture. Vessels, nerves, and bone tissue are essential constituents of bone system. Recently, increasing evidence has been revealed that LIPUS can not only promote bone regeneration by directly regulating osteoblasts, osteoblasts, mesenchymal stem cells, but also have a positive impact on the repair of bone healing through vessels and nerves. Thus, we reviewed and summarized the latest published literature about the molecular mechanism for the effects of LIPUS on bone regeneration, which might offer a promising therapy for bone-related diseases.

Key words: low-intensity pulsed ultrasound, bone regeneration, angiogenesis, nerve regeneration

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