华西口腔医学杂志 ›› 2021, Vol. 39 ›› Issue (2): 123-128.doi: 10.7518/hxkq.2021.02.001

• 专家论坛 •    

仿生策略用于口腔颌面部骨再生与牙种植的研究进展

蒋欣泉()   

  1. 上海交通大学医学院附属第九人民医院口腔修复科 上海交通大学口腔医学院 国家口腔疾病临床医学研究中心 上海口腔医学先进技术与材料工程技术研究中心 上海市口腔医学重点实验室 上海市口腔医学研究所,上海 200011
  • 收稿日期:2020-10-09 修回日期:2020-12-18 出版日期:2021-04-01 发布日期:2021-04-09
  • 通讯作者: 蒋欣泉 E-mail:xinquanjiang@aliyun.com
  • 作者简介:蒋欣泉,教授,博士,E-mail:xinquanjiang@aliyun.com
  • 基金资助:
    国家自然科学基金创新研究群体(81921002);国家重点研发计划(2016YFC1102900);国家自然科学基金重点国际(地区)合作研究项目(81620108006)

Advances in biomimetic modification of materials for oromaxillofacial bone regeneration and dental implant

Jiang Xinquan()   

  1. Dept. of Prosthodontics, Shanghai Ninth People, s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Clinical Research Center for Oral Diseases; Shanghai Engineering Research Center of Advanced Dental Technology and Materials; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai 200011, China
  • Received:2020-10-09 Revised:2020-12-18 Online:2021-04-01 Published:2021-04-09
  • Contact: Jiang Xinquan E-mail:xinquanjiang@aliyun.com
  • Supported by:
    Innovation Research Group of National Natural Science Foundation of China(81921002);The National Key Research and Development Program of China(2016YFC1102900);Key International (Regional) Cooperative Research Projects of National Natural Science Foundation of China(81620108006)

摘要:

肿瘤术后、外伤、牙周病、先天畸形等因素造成的口腔颌面部骨和牙等硬组织的缺损与缺失严重影响人的身心健康。如何有效保存和功能性修复口腔颌面部骨和牙等硬组织一直是临床治疗的重点和难题。基于组织工程技术的颌面部硬组织的再生治疗具有良好的临床应用前景。通过模拟生物的天然结构及成分对生物材料及干细胞投递方式进行仿生设计的策略,因其简洁、高效的优势逐渐成为研究热点。本文对目前仿生策略用于口腔颌面部骨再生与牙种植的研究进行综述,以期为口腔颌面部硬组织缺损和缺失的治疗提供新思路。

关键词: 口腔颌面部硬组织, 组织工程, 仿生设计, 微纳结构, 生物活性离子, 细胞膜片

Abstract:

Oromaxillofacial hard tissue defects is still a difficult problem in clinical treatment. Regeneration of oromaxillofacial hard tissue based on tissue engineering technology has a good clinical application prospect. The functional modification of scaffolds is one of key factors that influence the outcome of tissue regeneration. The biomimetic design of biomaterials through simulating the natural structure and composition of oromaxillofacial hard tissue has gradually become a research hotspot due to its advantages of simplicity and efficiency. In this article, the biomimetic modification of biomaterials for oromaxillofacial hard tissue regeneration is reviewed, expecting to provide a new idea for the treatment of oromaxillofacial hard tissue defect.

Key words: oromaxillofacial hard tissue, tissue engineering, biomimetic design, micro-nano structure, bioactive ions, cell sheet

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