West China Journal of Stomatology

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The Effect of Oral Carcinoma-associated Fibroblasts on the Invasion of Carcinoma Cell Line

LIN Jing-wen1, ZHOU Hong-mei2, LI Sheng-fu3, HU Tao1, CHEN Qian-ming2   

  1. 1. Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China; 2. Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China; 3. Laboratory of Transplantation Engi- neering and Transplantation Immunity, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2006-04-25 Revised:2006-04-25 Online:2006-04-20 Published:2006-04-20

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Abstract:

Objective  To observe the effect of oral carcinoma-associated fibroblasts（CAFs） on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma（OSCC） progression. Methods  Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113. Results  Compared with normal fibroblasts（NFs）, CAFs promoted more Tca8113 cells to penetrate Matrigel（P<0.05）. Conclusion  Oral CAFs can promote the invasion of lingual carcinoma cell line
Tca8113, and play a key role in OSCC progression.

Key words: carcinoma-associatedfibroblasts, oral, carcinomacellline, invasion

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