West China Journal of Stomatology ›› 2023, Vol. 41 ›› Issue (6): 701-707.doi: 10.7518/hxkq.2023.2023210

• Clinical Research • Previous Articles     Next Articles

Analysis of drug factors in 5-aminolevulinic acid photodynamic therapy for oral potentially malignant disorder

Li Dandan(), Yu Zhujun, Nie Cheng, Wang Jianli.   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-07-07 Revised:2023-09-28 Online:2023-12-01 Published:2023-11-27
  • Contact: Wang Jianli. E-mail:1126468651@qq.com
  • Supported by:
    Research and Develop Program, West China Hospital of Stomatology Sichuan University(RD-01-202309);Correspondence: Wang Jianli, E-mail: wangjianli0804@163.com


Objective This study aimed to analyze the influence of drug factors on the efficacy of 5-aminolevulinic acid (ALA) photodynamic therapy for oral potentially malignant disorder to improve clinical efficacy and promote clinical rational drug use. Methods Literature on the treatment of oral potentially malignant disorder by using ALA photodynamic therapy was collected and analyzed from PubMed, ISI Web of Knowledge database, CNKI, VIP, and Wanfang database. Results A total of 690 cases were collected, with an average complete response rate of 65.94%. The groups treated with 16.8% methyl aminolevulinate cream, local topical, once a week, and pre-activation time of 2-4 hours were better than the other subgroups, with average complete response rates of 100%, 66.91%, 78.28%, and 77.54%, respectively. Conclusion Drug factors have direct influence on the curative effect. The development of novel oral ALA formulations from the perspective of drug improvement is an important strategy to improve efficacy.

Key words: 5-aminolevulinic acid, photodynamic therapy, drug factors, oral potentially malignant disorder, novel formulations

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