Analysis of drug factors in 5-aminolevulinic acid photodynamic therapy for oral potentially malignant disorder

doi:10.7518/hxkq.2023.2023210

Abstract

Abstract:

Objective This study aimed to analyze the influence of drug factors on the efficacy of 5-aminolevulinic acid (ALA) photodynamic therapy for oral potentially malignant disorder to improve clinical efficacy and promote clinical rational drug use. Methods Literature on the treatment of oral potentially malignant disorder by using ALA photodynamic therapy was collected and analyzed from PubMed, ISI Web of Knowledge database, CNKI, VIP, and Wanfang database. Results A total of 690 cases were collected, with an average complete response rate of 65.94%. The groups treated with 16.8% methyl aminolevulinate cream, local topical, once a week, and pre-activation time of 2-4 hours were better than the other subgroups, with average complete response rates of 100%, 66.91%, 78.28%, and 77.54%, respectively. Conclusion Drug factors have direct influence on the curative effect. The development of novel oral ALA formulations from the perspective of drug improvement is an important strategy to improve efficacy.

Key words: 5-aminolevulinic acid, photodynamic therapy, drug factors, oral potentially malignant disorder, novel formulations

CLC Number:

R 781.5

Li Dandan, Yu Zhujun, Nie Cheng, Wang Jianli.. Analysis of drug factors in 5-aminolevulinic acid photodynamic therapy for oral potentially malignant disorder[J]. West China Journal of Stomatology, 2023, 41(6): 701-707.

Figures/Tables 6

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References 40

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疾病类型	样本数/例	完全缓解/例	完全缓解率/%	平均完全缓解率/%
合计	690	455	-	65.94
OLK	309	124	0~100	40.13
OE	95	88	0~100	92.63
OVH	105	104	80~100	99.05
OLP	181	139	0~100	76.80

剂型及浓度	疾病类型	样本数/例	完全缓解/例	平均完全缓解率/%
4%ALA凝胶	OLP	10	3	30.00
5%ALA凝胶	OLP	30	14	46.67
10%ALA凝胶	OLK	5	2	40.00
20%ALA凝胶	OLK	67	43	64.18
	OE	95	88	92.63
	OVH	105	104	99.05
	OLP	116	107	92.24
10%ALA乳膏	OLK	52	33	63.46
20%ALA乳膏	OLK	67	43	64.18
16.8%MAL乳膏	OLP	14	14	100.00
20%ALA水溶液	OLK	58	1	1.72
98%ALA水溶液	OLK	42	2	4.76
98%ALA水溶液	OLP	10	0	0.00
30 mg/kg ALA水溶液	OLK	18	0	0.00
118 mg ALA散剂	OLP	1	1	100.00

给药途径	疾病类型	样本数/例	完全缓解/例	平均完全缓解率/%
局部外用	OLK	296	122	41.22
	OE	95	88	92.63
	OVH	105	104	99.05
	OLP	181	139	76.80
口服	OLK	7	0	0.00
局部注射	OLK	6	2	33.33

给药频率	疾病类型	样本数/例	完全缓解/例	平均完全缓解率/%
单次	OLK	48	5	10.42
	OLP	1	1	100.00
每月1次	OLK	13	2	15.38
	OLP	35	25	71.43
每2周1次	OLK	96	71	73.96
每周1次	OLK	90	35	38.89
	OVH	105	104	99.05
	OE	95	88	92.63
每周2次	OLK	62	11	17.74
每周10次	OLP	145	113	77.93

预激活时间	疾病类型	样本数/例	完全缓解/例	平均完全缓解率/%
30 min	OLK	12	2	16.67
	OLP	10	0	0.00
1.5~2 h	OLK	157	17	10.83
	OE	95	88	92.63
	OVH	105	104	99.05
	OLP	157	125	79.62
2~4 h	OLK	124	93	75.00
	OLP	14	14	100.00
4~5 h	OLK	16	12	75.00