华西口腔医学杂志

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游离组织瓣移植同期修复下颌骨放射性骨坏死术后缺损

毛驰,俞光岩,彭歆,孙勇刚,张益,郭传   

  1. 北京大学口腔医院 口腔颌面外科,北京100081
  • 收稿日期:2004-08-25 修回日期:2004-08-25 出版日期:2004-08-20 发布日期:2004-08-20
  • 通讯作者: 毛 驰,Tel:010-62179977
  • 作者简介:毛 驰(1966-),男,浙江人,教授,博士

A Review of 11 Cases of Immediate Free Flap Transfer for Treating the Advanced Osteoradionecrosis of Mandible

MAO Chi,YUGuang-yan,PENGXin,SUN Yong-gang,ZHANG Yi,GUO Chuan-bin   

  1. Dept.of Oral and Maxillofacial Surgery School ofStomatology,Peking University,Beijing100081,China
  • Received:2004-08-25 Revised:2004-08-25 Online:2004-08-20 Published:2004-08-20

摘要:

目的 探讨游离组织瓣移植在晚期下颌骨放射性骨坏死治疗中的可靠性和应用价值。方法 采用游离组织瓣移植同期修复11例晚期下颌骨放射性骨坏死术后缺损的患者。分析原发肿瘤的部位和类型、放疗剂量、缺损的范围、所采用游离瓣的设计、受区血管的选择、游离瓣的成活情况及术后并发症的发生情况。结果 11例患者共采用15块游离组织瓣修复缺损,包括12块游离腓骨瓣、2块腹直肌皮瓣和1块前臂皮瓣。1例患者采用3块游离瓣修复(腓骨瓣、腹直肌瓣和前臂瓣),2例患者采用2块游离瓣修复(腓骨瓣和腓骨瓣,腓骨瓣和腹直肌瓣),余9 例患者各采用1块游离瓣修复。全部游离瓣均获得成活,无1例出现血管危象及组织瓣的全部或部分坏死。全部患者术后放射性骨坏死的症状均完全缓解,外形和功能也得到了不同程度的恢复,随访期间未见有肿瘤和放射性骨坏死复发。结论 对于晚期的下颌骨放射性骨坏死,采用病灶切除同期游离组织瓣移植是有效可行的方法,游离腓骨瓣是修复下颌骨缺损的首选。

关键词: 放射性骨坏死, 下颌骨, 游离组织瓣

Abstract:

Objective To assess the effectiveness and reliability of free flap transferfortreatingthe advanced osteoradionecrosis (ORN)of mandible.Methods Eleven cases of free flap transfer for treating the advanced ORN of mandible from October 1999 to February 2003 were reviewed. Data concerning the operation included site, stage and histology of primary tumor, dosage of radio- therapy, defect description, design of free flap, recipient vessel, free flap survival and complications.Results There were 8 males and 3 females, with age ranged 29-65 years old. Fifteen free flaps were used for reconstructing the defects, 12 were fibula flap, 2 were rectus abdominismyocutaneous flap, and 1 was radial forearmflap. All the free flaps survived completelywithout par- tial or total necrosis. The complication rate was 36.4%. All patients had complete resolution of ORN symptoms. No evidence of ORNrecurrencewas observed in any patient.Conclusion Free flap transfer provides a reliable and effective means fortreatingthe advanced ORN of mandible. Free fibula flap is the workhorse flap for reconstruction of mandible.

Key words: osteoradionecrosis, mandible, free flap