低氧环境下的口腔稳态失衡

doi:10.7518/hxkq.2026.2025427

华西口腔医学杂志 ›› 2026, Vol. 44 ›› Issue (2): 215-223.doi: 10.7518/hxkq.2026.2025427

• 观点·述评 • 上一篇

低氧环境下的口腔稳态失衡

徐一帆¹^,²^,³(), 王松灵²(), 周建²^,³^,⁴^,⁵()

^1.首都医科大学附属北京口腔医院种植科，北京 100070
^2.首都医科大学口腔健康北京实验室，北京 100069
^3.首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室，北京 100069
^4.首都医科大学附属北京口腔医院国际医疗部，北京 100070
^5.首都医科大学附属北京天坛医院口腔和全身健康融合与转化研究实验室，北京 100070

收稿日期:2025-10-27 出版日期:2026-04-01 发布日期:2026-03-31
通讯作者: 王松灵,周建 E-mail:dgdxyf813@126.com;slwang@ccmu.edu.cn;zhoujian@ccmu.edu.cn
作者简介:徐一帆，医师，博士，E-mail：dgdxyf813@126.com|王松灵，中国科学院院士，中国医学科学院学术咨询委员会学部委员。南方科技大学医学院院长，南方科技大学稳态医学院研究院院长，首都医科大学健康大数据国家研究院院长，中国抗衰老促进会理事长，中华口腔医学会副会长，口腔健康北京实验室主任。国务院学位委员会第8届口腔医学召集人，全国口腔医学教材专家委员会主任委员，全国统编八年制及“5+3一体化”教材《口腔医学》及《硝酸盐与机体稳态》等主编。《中华口腔医学杂志》总编辑、《医学教育管理》主编、《今日口腔》主编。发表论文279篇，其中以主要作者发表英文论文187篇。以第一完成人获得2003、2010年国家科技进步奖二等奖2项；获得威廉盖茨（William J. Gies）奖、吴阶平医药创新奖、何梁何利科学技术奖等。研究方向为稳态医学、牙颌发育与再生、唾液腺疾病诊疗。发现人细胞膜硝酸盐转运通道，创立并阐释稳态医学的概念，研发基于硝酸盐的新药；揭示牙发育新机制，研发牙髓干细胞新药，成功实现生物性牙齿再生。|周建，教授，主任医师，博士生导师，北京高层次创新创业人才支持计划领军人才，首都医科大学科技处副处长、首都医科大学附属北京口腔医院科技处副处长。兼任中华医学会医学科学管理学分会委员、中华口腔医学会口腔生物医学专业委员会常务委员、中华口腔医学会牙及牙槽外科专业委员会委员、《中华口腔医学》杂志通讯编委等职务。临床与研究工作聚焦种植和牙槽外科，牵头多中心临床研究2项。以第一、通信作者身份发表论文50余篇（其中SCI论文21篇），获国家自然科学基金（5项）、北京市自然科学基金、首都卫生发展科研专项等项目资助。主译口腔医学史著作《如齿神奇》，主编、副主编专著4部，参编全国高等学校八年制及“5+3”一体化临床医学专业第4轮规划教材《口腔医学》。以第一发明人获批专利15项，累计转化金额320万元。
基金资助:
北京市政府资助项目（口腔健康北京实验室,PXM20;21_014226_000041;国家自然科学基金(81741106);国家自然科学基金(82470961);北京高层次创新创业人才支持计划领军人才项目(G202512061);首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室资助项目［（2023）175］;首都医科大学附属北京口腔医院青年科技创新人才培育计划(YSP202408)

Oral homeostasis imbalance under hypoxia

Xu Yifan¹^,²^,³(), Wang Songling²(), Zhou Jian²^,³^,⁴^,⁵()

^1.Dept. of Oral Implantology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China
^2.Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China
^3.Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China
^4.Dept. of International Medical Center, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China
^5.Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Received:2025-10-27 Online:2026-04-01 Published:2026-03-31
Contact: Wang Songling,Zhou Jian E-mail:dgdxyf813@126.com;slwang@ccmu.edu.cn;zhoujian@ccmu.edu.cn
Supported by:
Natio-nal Natural Science Foundation of China(81741106);Beijing High-Level Innovation and Entrepreneurship Talent Support Program Leading Talent Projects(G202512061);Young Scientist Program of Beijing Stomatological Hospital, Capital Medical University(YSP202408);Beijing Municipal Government Grant (Beijing Laboratory of Oral Health, PXM2021_014226_000041);Projeot of Laboratory for Clinical Medicine (Capital Medical University)((2023)175)

摘要/Abstract

摘要：

低氧通过干扰牙胚发育过程，损害唾液腺功能与唾液缓冲能力、口腔黏膜屏障完整性、颌骨及牙槽骨改建平衡，以及口腔微生物群落的多样性和功能等，导致口腔稳态失衡，进而引起多种口腔疾病的发生与发展。同时，口腔稳态的失衡还可通过炎症因子及微生物群移位等机制，影响全身稳态并增加其他系统疾病风险。本文系统梳理了低氧暴露对口腔稳态的影响及机制，并探讨低氧口腔稳态失衡与全身稳态失衡的关联，旨在为深入理解低氧口腔稳态和全身稳态调控的机制以及维持策略研究提供参考。

关键词: 低氧, 口腔稳态, 唾液腺, 口腔黏膜屏障, 颌骨, 口腔微生物群, 全身稳态

Abstract:

Hypoxia disrupts oral homeostasis through multiple interconnected pathways, including interference with tooth germ development, impairment of salivary gland function and salivary buffering capacity, compromise of the oral mucosal barrier, imbalance in jawbone and alveolar bone remodeling, and alterations in the diversity and functionality of the oral microbiome. These disturbances collectively contribute to the onset and progression of oral diseases. Moreover, disruption of oral homeostasis may, in turn, affect systemic homeostasis, increasing the risk of disorders in other organ systems through mechanisms involving inflammatory mediator release and microbial translocation. Here, we systematically review the effects and underlying mechanisms of hypoxia exposure on oral homeostasis, and further explore the interconnections between hypoxia-induced oral dysregulation and systemic homeostatic imbalance. This review aims to provide a comprehensive understanding of the regulatory networks linking oral and systemic homeostasis under hypoxia, thereby offering potential insights for maintaining homeostatic balance.

Key words: hypoxia, oral homeostasis, salivary gland, oral mucosal barrier, jawbone, oral microbiome, systemic homeostasis

中图分类号:

徐一帆, 王松灵, 周建. 低氧环境下的口腔稳态失衡[J]. 华西口腔医学杂志, 2026, 44(2): 215-223.

Xu Yifan, Wang Songling, Zhou Jian. Oral homeostasis imbalance under hypoxia[J]. West China Journal of Stomatology, 2026, 44(2): 215-223.

图/表 1

参考文献 48

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低氧环境下的口腔稳态失衡

Oral homeostasis imbalance under hypoxia

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