Abstract:

Objective　To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.Methods　The expression ofAng-1 and Ang-2 protein in samples from42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.Results　The expres- sion of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. Itwas found Ang-1 expression alike in oral squamous cell carcinoma and control (P>0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P<0.05).Conclusion　Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classifi- cation, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell car- cinoma.

Key words: angiopoietin, oral squamous cell carcinoma, immunohistochemistry