Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor

doi:10.7518/hxkq.2023.2023035

Abstract

Abstract:

Objective To analyze the clinicopathological features of maxillofacial granular cell tumors (GCT) with the aid of immunohistochemical staining. Methods Seven cases of maxillofacial GCT were retrospectively collated, and the microscopic morphology of maxillofacial GCT was analyzed. The expression of S-100, neuron-specific enolase (NSE), SOX-10, CD68, actin, desmin, and Ki-67 in GCT was detected by immunohistochemical staining. The cases were observed in the follow-ups after clinical treatment. Results All seven GCT tumors lacked envelopes and were poorly defined. Microscopically, the sizes of the tumor cells were large and appeared with inconspicuous cell membranes, forming a syncytium-like appearance. The cytoplasm was filled with characteristic eosinophilic granules. The immunohistochemical results showed that six cases were NSE-positive, five cases were S-100-positive, seven cases were CD68-positive, five cases were SOX-10-positive, one case was actin-positive, and seven cases were desmin-negative. The Ki-67 index did not exceed 5% in all cases. In the follow-up sessions, none of the six cases presented a recurrence. Conclusion Maxillofacial GCT has a characteristic histological structure. Immunohistochemical S-100, CD68, and other indicators can assist in diagnosis, and the prognosis is good after clinical resection.

Key words: granular cell tumor, clinicopathology, immunohistochemistry

CLC Number:

R 739.8

Shen Zeliang, Yao Lihong, Jiang Hongjie, Li Mao, Tang Yaling.. Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor[J]. West China Journal of Stomatology, 2023, 41(4): 414-420.

Figures/Tables 5

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序号	确诊年份	性别	年龄/岁	部位	肿瘤最大直径/mm	病程	治疗方式	随访情况	随访时间/月
1	2013	女	44	舌背	20	1年	L	无复发	109
2	2014	女	19	左下牙龈	5	6个月	L	无复发	108
3	2014	女	14	右舌缘	30	1年余	G	无复发	100
4	2018	女	39	右舌缘	5	1年	L	无复发	55
5	2020	女	35	左颊黏膜	10	2年	G	无复发	25
6	2021	男	4	左舌腹	25	1年	G	无复发	15
7	2022	男	33	右侧舌背	15	6个月	G	手术时间不足1年，未随访	-

序号	生长模式	炎细胞浸润	侵犯肌肉	侵犯神经	侵犯血管	有假上皮瘤样增生	有上皮内肿瘤岛
1	侵袭性	-	+	+	+	+	+
2	侵袭性	-	-	-	+	+	+
3	侵袭性	-	+	+	+	+	+
4	侵袭性	-	+	-	+	+	+
5	侵袭性	+	-	-	+	+	+
6	侵袭性	+	+	-	+	-	-
7	侵袭性	+	+	+	+	+	+

序号	NSE	S-100	CD68	SOX-10	Actin	Desmin	Ki-67
1	+	+	+	+	-	-	<1% +
2	-	-	+	-	-	-	3% +
3	+	+	+	部分+	-	-	1% +
4	+	+	+	+	-	-	<1% +
5	+	+	+	+	-	-	<1% +
6	+	-	+	-	+	-	3%~5% +
7	+	+	+	+	-	-	<1% +

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