West China Journal of Stomatology

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New finding of the expression of human β defensin-4 in healthy gingiva

Li Xinyi1, Duan Dingyu1, Wang Panpan1, Han Bo2, Xu Yi1.   

  1. 1. State Key Laboratory of Oral Diseases, Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; 2. State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Online:2013-04-01 Published:2013-04-01

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Abstract:

Objective  To investigate the expression and the distribution of human β defensin (hBD)-4 in healthy gingiva. Methods  Healthy gingival specimens were collected. The expression of hBD-4 peptides in 18 gingival specimens were detected by immunohistochemistry. The hBD-4 mRNA were determined in freshly isolated gingival tissue by real time reverse transcription-polymerase chain reaction (real time RT-PCR) in 30 gingival specimens. Results  In 18 gingival specimens, hBD-4 peptides were expressed in 13 gingival specimens. In 30 gingival specimens, hBD-4 were detected in 4 gingival specimens by real time RT-PCR. Conclusion  The distribution and the expression levels of hBD-4 are different in healthy gingiva. This result may suggest that the hBD-4 play a role in maintaining the periodontal health.

Key words: gingiva, human &beta, defensin -4, immunohistochemistry, real time reverse transcription-polymerase chain reaction

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