华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (3): 330-337.doi: 10.7518/hxkq.2020.03.018

• 综述 • 上一篇    下一篇

非编码RNA在人牙周膜来源细胞成骨分化中的作用

温佳慧, 吴燕岷(), 陈莉丽   

  1. 浙江大学医学院附属第二医院牙周科,杭州 310009
  • 收稿日期:2019-02-21 修回日期:2019-12-19 出版日期:2020-06-01 发布日期:2020-05-28
  • 通讯作者: 吴燕岷 E-mail:wuyanmin@zju.edu.cn
  • 作者简介:温佳慧,硕士,E-mail: 21618162@zju.edu.cn
  • 基金资助:
    浙江省基础公益研究计划(LGF18H140003)

Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Wen Jiahui, Wu Yanmin(), Chen Lili   

  1. Dept. of Periodontology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2019-02-21 Revised:2019-12-19 Online:2020-06-01 Published:2020-05-28
  • Contact: Yanmin Wu E-mail:wuyanmin@zju.edu.cn
  • Supported by:
    Zhejiang Basic Public Welfare Research Program(LGF18H140003)

摘要:

人牙周膜来源细胞是牙周再生的重要种子细胞,其成骨潜能密切影响牙槽骨修复和牙周再生。非编码RNA(ncRNA)积极参与调控人牙周膜来源细胞的成骨基因,其主要包括微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)等。本文就ncRNA在人牙周膜来源细胞成骨分化的调控靶点、作用通路及发挥功能的研究进展进行综述。

关键词: 微小RNA, 长链非编码RNA, 环状RNA, 牙周膜细胞, 牙周膜干细胞, 成骨分化

Abstract:

Human periodontal ligament-derived cells serve as an important source of seeding cells in periodontal regenerative medicine, and their osteogenic potential is closely related to alveolar bone repair and periodontal regeneration. Non-coding RNA (ncRNA), such as microRNA, long non-coding RNA, and circular RNA, play important roles in the regulation of osteogenic genes in human periodontal ligament-derived cells. In this review, we summarize the target genes, pathways, and functions of the ncRNA network during osteogenic differentiation of periodontal ligament-derived cells.

Key words: microRNA, long non-coding RNA, circular RNA, periodontal ligament cell, periodontal ligament stem cell, osteogenic differentiation

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