华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (3): 325-329.doi: 10.7518/hxkq.2019.03.019

• 综述 • 上一篇    下一篇

引导骨再生屏障膜改良的研究进展

曹钰彬1,刘畅2,潘韦霖2,涂缘1,李春洁1,3,华成舸2,3()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院头颈肿瘤外科
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院口腔颌面外科
    3.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院循证口腔医学教研室,成都 610041
  • 收稿日期:2018-06-21 修回日期:2019-02-19 出版日期:2019-06-01 发布日期:2019-06-12
  • 通讯作者: 华成舸 E-mail:huacg@163.com
  • 作者简介:曹钰彬,博士,E-mail:yubin.cao@qq.com
  • 基金资助:
    四川省重点研发项目(2018SZ0181)

Research progress on the modification of guided bone regeneration membranes

Yubin Cao1,Chang Liu2,Weilin Pan2,Yuan Tu1,Chunjie Li1,3,Chengge Hua2,3()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    3.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Evidence-based Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-06-21 Revised:2019-02-19 Online:2019-06-01 Published:2019-06-12
  • Contact: Chengge Hua E-mail:huacg@163.com
  • Supported by:
    Key Research and Development Foundation of Sichuan Province(2018SZ0181)

摘要:

引导骨再生术是解决骨组织缺损问题的重要技术,引导骨再生屏障膜在其中发挥着不可替代的作用。引导骨再生膜是防止成纤维细胞进入骨缺损部位的屏障,同时可促进成骨细胞的黏附、增殖和骨组织再生。由于目前广泛应用于引导骨再生的胶原膜尚存在一些缺陷,探索具有更优良性质的引导骨再生屏障膜成为一个重要的课题。因此出现了从抗菌性的改良、成骨性的改良和新材料的研发等多方面的努力以改良引导骨再生膜。本文回顾了近年来引导骨再生膜改进的研究成果和进展,展望了未来相关研究的发展方向,为进一步展开骨再生及修复的相关研究工作提供参考。

关键词: 引导骨再生, 骨组织工程, 生物膜, 胶原膜

Abstract:

Guided bone regeneration (GBR) is an important technique to solve bone defect problems. In this technique, GBR barrier membranes play an irreplaceable role. GBR membranes can act as a barrier protecting fibroblasts from bone defects and promote osteoblast adhesion and proliferation, leading to bone regeneration. GBR barrier membranes should be enhanced because of the disadvantages of collagen membranes, which are extensively applied to the field of GBR. Therefore, various efforts have been devoted to modifying the antibacterial and osteogenic properties of GBR barrier membranes and developing novel materials. This article reviews the research advancements on the modification of GBR barrier membranes and discover future directions for the development of GBR barrier membranes to provide a reference for bone tissue engineering and repair.

Key words: guided bone regeneration, bone tissue engineering, biological membrane, collagen membrane

中图分类号: