West China Journal of Stomatology ›› 2023, Vol. 41 ›› Issue (5): 592-598.doi: 10.7518/hxkq.2023.2023084

• Case Report • Previous Articles     Next Articles

Oral mucosal lesions with transient self-healing of Langerhans cell histiocytosis: a case report

Zhang Xiaoling(), Xue Ningning, Ruan Minhui, Zeng Xin.()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-03-21 Revised:2023-05-22 Online:2023-10-01 Published:2023-10-08
  • Contact: Zeng Xin. E-mail:zhangxl123@stu.scu.edu.cn;zengxin22@163.com
  • Supported by:
    The National Natural Science Foundation of China(U19A2005);Clinical and Translational Medicine Research Fund of Chinese Academy of Medical Sciences(2020-I2M-C&T-A-023)


Langerhans cell histiocytosis (LCH) is a group of unexplainable abnormal proliferation and aggregation of Langerhans cell. LCH can be classified into four clinical variants: Letterer-Siwe disease, Hand-Schüller-Christian disease, eosinophilic granuloma, and congenital self-healing LCH. LCH is most prevalent in children. Lesions can be localized in a single system or multiple organs, and clinical manifestations vary depending on the affected organs. The skin and mucocutaneous tissues are the starting point of the affected tissue. This study presents a LCH case characterized by transient self-healing. This case can further provide references for the clinical diagnosis and treatment of LCH.

Key words: Langerhans cell histiocytosis, self-healing, oral ulcer, diagnosis

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