Multifocal eosinophilic granuloma of the jaws with long-term follow-up: a case report

doi:10.7518/hxkq.2021.03.017

Abstract

Abstract:

Eosinophilic granuloma, a rare disease, has various clinical manifestations and no specific X-rays features and is thus easily misdiagnosed. This paper reports a case of multifocal eosinophilic granuloma of jaw with long-term follow-up. The patient initially presented with periodontal tissue destruction.The diagnosis, treatment and prognosis of multifocal eosinophilic granuloma of jaw were discussed in combination with the literature to alert this disease in clinical practice.

Key words: eosinophic granuloma of the jaws, long-term follow-up, diagnosis

CLC Number:

R 739.8

Si Yuchen, Liu Qian, Hou Haijuan, Huang Ping. Multifocal eosinophilic granuloma of the jaws with long-term follow-up: a case report[J]. West China Journal of Stomatology, 2021, 39(3): 355-361.

Figures/Tables 5

References 35

1	于世凤.口腔组织病理学[M]. 7版. 北京: 人民卫生出版社, 2012: 259-261.
	Yu SF. Oral histopathology[M]. 7th ed. Beijing: People's Medical Publishing House, 2012: 259-261.
2	王新木, 马威, 封兴华. 颌骨嗜酸性肉芽肿临床病理回顾性研究[J]. 口腔医学研究, 2004, 20(2): 201-202.
	Wang XM, Ma W, Feng XH. Retrospective study of clinical pathological of jawbone eosinophilic granuloma[J]. J Oral Sci Res, 2004, 20(2): 201-202.
3	余问桥, 郑光勇, 梁新华. 颌面部骨嗜酸性肉芽肿18例临床分析[J]. 口腔颌面外科杂志, 2006, 16(4): 333-334, 345.
	Yu WQ, Zheng GY, Liang XH. Clinical analysis of eosinophilic granuloma of bone in maxillofacial region: 18 cases report[J]. Chin J Oral Maxillofac Surg, 2006, 16(4): 333-334, 345.
4	吕标, 陶谦. 颌骨嗜酸性肉芽肿的临床特点[J]. 国际口腔医学杂志, 2008, 35(2): 201-203.
	Lü B, Tao Q. Clinical features of eosinophilic granuloma of jaw[J]. Int J Stomatol, 2008, 35(2): 201-203.
5	Raviraj J, Venkata S, Shaik S, et al. Multifocal eosinophilic granuloma of jaws and skull with classical and unusual radiographic/imaging findings[J]. J Clin Diagn Res, 2017, 11(1): ZD9-ZD11.
6	Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent BRAF mutations in Langerhans cell Histiocytosis[J]. Blood, 2010, 116(11): 1919-1923.
7	Silvestros SS, Mamalis AA, Sklavounou AD, et al. Eosinophilic granuloma masquerading as aggressive periodontitis[J]. J Periodontol, 2006, 77(5): 917-921.
8	陶谦, 曾融生, 苏凯, 等. 颌骨嗜酸性肉芽肿的临床特点——文献复习及1例报告[J]. 口腔医学, 2007, 27(10): 516-518.
	Tao Q, Zeng RS, Su K, et al. Clinical characteristics of eosinophilic granuloma of jaws: literature reviews and a case report[J]. Stomatology, 2007, 27(10): 516-518.
9	dos Anjos Pontual ML, da Silveira MM, de Assis Silva Lima F, et al. Eosinophilic granuloma in the jaws[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 104(6): e47-e51.
10	石利强, 孟庆江, 王艳清, 等. 颌骨嗜酸性肉芽肿临床X线分析[J]. 中国临床医学影像杂志, 2002, 13(3): 224-225.
	Shi LQ, Meng QJ, Wang YQ, et al. X-ray analysis of eosinophilic granuloma of bone in jaws[J]. J China Clin Med Imag, 2002, 13(3): 224-225.
11	Zhi L, Li ZB, Wei Z, et al. Eosinophilic granuloma of the jaws: an analysis of clinical and radiographic presentation[J]. Oral Oncol, 2006, 42(6): 574-580.
12	陆东辉, 陈菲, 王铁梅, 等. 15例颌骨嗜酸性肉芽肿的临床与病理研究[J]. 华西口腔医学杂志, 2005, 23(5): 450-451.
	Lu DH, Chen F, Wang TM, et al. Clinical and pathological study of eosinophilic granuloma of the jaw in 15 cases[J]. West China J Stomatol, 2005, 23(5): 450-451.
13	Eckardt A, Schultze A. Maxillofacial manifestations of Langerhans cell histiocytosis: a clinical and therapeutic analysis of 10 patients[J]. Oral Oncol, 2003, 39(7): 687-694.
14	邵山, 郑家伟, 邵宇, 等. 颌骨嗜酸性粒细胞肉芽肿21例临床分析[J]. 上海口腔医学, 2004, 13(4): 328-330.
	Shao S, Zheng JW, Shao Y, et al. Eosinophilic granuloma of the jaw: an analysis of 21 cases[J]. Shanghai J Stomatol, 2004, 13(4): 328-330.
15	Histiocytosis syndromes in children. Writing group of the histiocyte society[J]. Lancet, 1987, 1(8526): 208-209.
16	Asaumi J, Konouchi H, Hisatomi M, et al. Two cases of polyostotic eosinophilic granuloma[J]. Dentomaxillofac Radiol, 2000, 29(6): 382-385.
17	韩金友, 王旭霞, 张立新. 颌骨嗜酸性肉芽肿(附二例报告)[J]. 临床口腔医学杂志, 1998, 14(4): 251-253.
	Han JY, Wang XX, Zhang LX. Eosinophilic granuloma of jaw (two cases report)[J]. J Clin Stomatol, 1998, 14(4): 251-253.
18	Berres ML, Lim KP, Peters T, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups[J]. J Exp Med, 2014, 211(4): 669-683.
19	Watzke IM, Millesi W, Kermer C, et al. Multifocal eosinophilic granuloma of the jaw: long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000, 90(3): 317-322.
20	Whitcher BL, Webb DJ. Treatment of recurrent eosinophilic granuloma of the mandible following radiation the-rapy[J]. J Oral Maxillofac Surg, 1986, 44(7): 565-570.
21	Bhaskar PB, White CS, Baughman RA. Eosinophilic gra-nuloma of the mandibular condyle. A case report and ma-nagement discussion[J]. Oral Surg Oral Med Oral Pathol, 1993, 76(5): 557-560.
22	Anwar MA, Murad F, Dawson E, et al. Immunohistoche-mistry as a reliable method for detection of BRAF-V600E mutation in melanoma: a systematic review and Meta-analysis of current published literature[J]. J Surg Res, 2016, 203(2): 407-415.
23	Sahm F, Capper D, Preusser M, et al. BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis[J]. Blood, 2012, 120(12): e28-e34.
24	Roden AC, Hu XW, Kip S, et al. BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases[J]. Am J Surg Pathol, 2014, 38(4): 548-551.
25	Alayed K, Medeiros LJ, Patel KP, et al. BRAF and MA-P2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases[J]. Hum Pathol, 2016, 52: 61-67.
26	Wei R, Wang ZQ, Li XL, et al. Frequent BRAFV600E mutation has no effect on tumor invasiveness in patients with Langerhans cell histiocytosis[J]. Biomed Rep, 2013, 1(3): 365-368.
27	程晓烨, 李妍, 周军, 等. 中国人群朗格汉斯组织细胞增生症患者BRAF V600E突变及临床意义[J]. 中国实验血液学杂志, 2015, 23(2): 526-532.
	Cheng XY, Li Y, Zhou J, et al. BRAF V600E mutation in Chinese patients with Langerhans cell histiocytosis and its clinical significance[J]. J Exp Hematol, 2015, 23(2): 526-532.
28	Berres ML, Lim KP, Peters T, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups[J]. J Exp Med, 2014, 211(4): 669-683.
29	Méhes G, Irsai G, Bedekovics J, et al. Activating BRAF V600E mutation in aggressive pediatric Langerhans cell histiocytosis: demonstration by allele-specific PCR/direct sequencing and immunohistochemistry[J]. Am J Surg Pa-thol, 2014, 38(12): 1644-1648.
30	Hervier B, Haroche J, Arnaud L, et al. Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation[J]. Blood, 2014, 124(7): 1119-1126.
31	Schilling B, Sondermann W, Zhao F, et al. Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma[J]. Ann Oncol, 2014, 25(3): 747-753.
32	Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib[J]. N Engl J Med, 2012, 366(8): 707-714.
33	Gandolfi L, Adamo S, Pileri A, et al. Multisystemic and multiresistant Langerhans cell histiocytosis: a case treated with BRAF inhibitor[J]. J Natl Compr Canc Netw, 2015, 13(6): 715-718.
34	Haroche J, Cohen-Aubart F, Emile JF, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation[J]. Blood, 2013, 121(9): 1495-1500.
35	Euskirchen P, Haroche J, Emile JF, et al. Complete remission of critical neurohistiocytosis by vemurafenib[J]. Neurol Neuroimmunol Neuroinflamm, 2015, 2(2): e78.

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