West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (3): 300-305.doi: 10.7518/hxkq.2021.03.009

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Salivary biochemical indices related to early childhood caries

Zhang Ying1,2(), Jia Songbo3, Li Fan1,2, Li Shanshan1, Zhang Lijuan1,2, Tan Kaixuan2, Lu Jie2, Yang Fang2()   

  1. 1.School of Stomatology, Qingdao University, Qingdao 266003, China
    2.Stomatology Center, Qingdao Municipal Hospital, Qingdao 266071, China
    3.Dept. of Stomatology, Tianjin Children, s Hospital, Tianjin 300074, China
  • Received:2020-05-26 Revised:2021-02-13 Online:2021-06-01 Published:2021-05-26
  • Contact: Yang Fang E-mail:15162731585@163.com;yangf82@sina.com
  • Supported by:
    The National Natural Science Foundation of China(81670979)

Abstract: Objective

This study aimed to compare the salivary biochemical indices between caries-free individuals and those with early childhood caries (ECC), and construct a saliva-based caries diagnostic model by analyzing the correlation between salivary biochemical indices and caries severity.


A total of 120 children aged 4-6 years were selected and divided into two groups: individuals with ECC (C group, n=60) and healthy children (H group, n=60). Salivary samples were collected to compare the pH, total protein, and ion concentrations between the two groups. The correlation between the salivary biochemical indices and caries severity was examined, and an ECC diagnostic model was established.


The NO3- concentration significantly decreased in the C group, whereas the Cl-, Br-, NH4+, and Mg2+ concentrations significantly increased in the C group (P<0.05). In addition, the salivary caries severity had a significantly negative correlation with the NO3- concentration but had a positive correlation with Br-, Cl-, and NH4+ concentrations (P<0.05). The ECC diagnostic model based on salivary biochemical indices could yield satisfactory results in terms of distinguishing the C and H groups with over 85% accuracy.


Salivary biochemical indices can contribute to the diagnosis and risk assessment of ECC.

Key words: early childhood caries, saliva, biochemical indices, correlation, diagnosis model

CLC Number: