West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (1): 99-104.doi: 10.7518/hxkq.2021.01.015

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Advances on mechanism and treatment of salivary gland in radiation injury

Li Shensui(), Wu Chenzhou, Qiao Xianghe, Li Chunjie, Li Longjiang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-04-16 Revised:2020-05-28 Online:2021-02-01 Published:2021-03-02
  • Contact: Li Longjiang E-mail:644551880@qq.com;muzili63@163.com
  • Supported by:
    The National Natural Science Foundation of China(81870782)

Abstract:

Oral squamous cell carcinoma (OSCC) is the most frequent tumour in head and neck malignant. The current treatment is mainly based on surgery therapy, radiation therapy and chemical therapy. Meanwhile, there are many a defect in the treatment. For example, there are many defects in radiotherapy. Radioactive salivatitis is the most common. In addition, there are a series of changes such as dry mouth, oral mucositis, rampant dental caries, and radioactive osteomyelitis of jaw, which cause swallowing, chewing problems, and taste dysfunction. Currently, the research on radioactive salivatitis is progressing rapidly, but its mechanism is more complication. This paper review aims to summarize the research progress in this field.

Key words: radioactive salivatitis, radiation injury, aquaporion, apoptosis

CLC Number: