A Meta-analysis of the effect of non-surgical periodontal therapy on inflammatory factors in patients with chronic kidney disease and periodontitis

doi:10.7518/hxkq.2020.06.012

Abstract

Abstract:

Objective A study was conducted to systematically evaluate the clinical efficacy of inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy. Methods We searched the databases of CNKI, Wanfang, CBM, PubMed, Embase, and Cochrane Library from inception to December 2019. Two reviewers independently collected all literature related to inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy. These factors include C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The literature was screened according to the inclusion and exclusion criteria. The quality of the studies was strictly evaluated, and the data were extracted. The literature of randomized controlled trials in accordance with the standards was Meta-analyzed with Revman 5.3 software. Results Six randomized controlled trials were included. Compared with the control groups, the results of meta-analysis showed that non-surgical periodontal therapy significantly reduced the levels of CRP [MD=-0.58, 95%CI (-1.13, -0.02), P=0.04] and IL-6 [MD=-2.76, 95%CI (-5.15, -0.37), P=0.02] in these patients but not that of TNF-α [MD=-3.87, 95%CI (-8.79, 1.05), P=0.12]. Conclusion Simultaneous regular renal treatment and non-surgical periodontal therapy can help relieve the periodontal damage on patients with chronic kidney disease and periodontitis. Moreover, it can improve the status of some inflammatory factors. This finding is conducive to the control and treatment of chronic kidney disease and periodontitis and needs to be a focus of research and in clinical operation.

Key words: chronic kidney disease, periodontitis, periodontal therapy, C-reactive protein, interleukin-6, tumor necrosis factor-α

CLC Number:

R781.4

Lai Jing, Bai Yuanliang, Bai Yin, Mei Jie, Zhang Zhiwei, Tang Wenjing, Huang Jiao. A Meta-analysis of the effect of non-surgical periodontal therapy on inflammatory factors in patients with chronic kidney disease and periodontitis[J]. West China Journal of Stomatology, 2020, 38(6): 672-680.

Figures/Tables 7

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纳入研究	年份	年龄/岁	样本量	性别	时间点	治疗方式	测量指标
纳入研究	年份	年龄/岁	（T/C）	（男/女）	时间点	治疗方式	测量指标
Wehmeyer等^[24]	2013	53.4±9.8	23/23	33/18	3个月、6个月	腹膜透析	IL-6、白蛋白
Fang等^[25]	2015	54.62±6.32	48/49	42/55	6周、3个月、6个月	血液透析	TNF-α、IL-6、CRP、铁蛋白等
Guo等^[26]	2017	57.5±8.5	26/27	24/29	6周	常规肾病治疗	TNF-α、IL-6、CRP
张晋玮等^[27]	2017	48.61±4.60	31/30	30/31	1个月	腹膜透析	CRP
李浩萍等^[28]	2018	40.28±6.30	36/36	39/33	8周	血液透析	TNF-α、IL-6、CRP、血清肌酐、24 h尿蛋白
马欣等^[29]	2018	39.2±5.2	52/46	56/42	6周	血液透析	TNF-α、IL-6、CRP、血清肌酐、24 h尿蛋白