Expr ession of Inducible Nitr ic Oxide Synthase in Cartilage in Progr ession of Temporomandibular Joint Osteoarthritis

West China Journal of Stomatology

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Expr ession of Inducible Nitr ic Oxide Synthase in Cartilage in Progr ession of Temporomandibular Joint Osteoarthritis

GAO Zhan- wei1，2, WANG Da- zhang3, LIU Bao- lin2, MA Hai - huan1

1. Dept. of Plastic Surgery, China - Japan Friendship Hospital, Beijing 100029, China; 2. Dept. of Oral and Maxillofacial Surgery, The Fourth Military Medical University, Xi′an 710032, China; 3. Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China

Received:2007-06-25 Revised:2007-06-25 Online:2007-06-20 Published:2007-06-20
Contact: WANG Da- zhang，Tel：028- 85501934

Abstract

Abstract:

Objective To study the expression of inducible nitric oxide synthase（iNOS） in cartilage of temporomandibular joint osteoarthriti（TMJOA）, and to evaluate the role of iNOS in the progression of TMJOA. Methods The goats were used and TMJOA was induced by injection of collagenase in upper joint space. The joints were obtained and were investigated by using immunohistochemistry at 2, 4, 12, 24 weeks after injection. Results Almost no expression of iNOS in normal cartilage of TMJ. In the diseased joints, strong or definite iNOS reactivity was expressed. Conclusion iNOS plays an important role in the progression of TMJOA.

Key words: temporomandibular joint osteoarthritis, inducible nitric oxide synthase, cartilage

GAO Zhan- wei1，2, WANG Da- zhang3, LIU Bao- lin2, MA Hai - huan1. Expr ession of Inducible Nitr ic Oxide Synthase in Cartilage in Progr ession of Temporomandibular Joint Osteoarthritis[J]. West China Journal of Stomatology.

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Expr ession of Inducible Nitr ic Oxide Synthase in Cartilage in Progr ession of Temporomandibular Joint Osteoarthritis

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