Abstract:

Objective　To study the expression of Runx2/Cbfa1 in the developing dentin and differentiating odontoblasts.Meth- ods　A postnatal mice teeth developing model was built histologically. Immunohistochemical technique was adopted to determine the expression of Runx2/Cbfa1 in the developing pulpo-dentinal complex in mice.Results　Runx2/Cbfa1 was merely present in predentin in the exact and before the 11th day′s postnatal stages. Meanwhile, it was positively located in odontoblasts and dental pulp cells in root region, but negatively in coral part after the 11th day′s stages.Conclusion　Runx2/Cbfa1 may play an impor- tant role in the deposing of tooth dentin and in the differentiating of odontoblasts and pulp cells.

Key words: Runx2/Cbfa1, immunohistochemistry, pulpo-dentinal complex, development