Abstract:

Objective:The aim of this study is to compare activities of phospholipase ofCandida albicansisolatesfrom oral cavities of two groups of patients, including oral pre-malignant lesions and oral cancers.Methods:A total of 55 isolates, including oral pre-ma- lignant lesions (21), oral cancers (15), and normal health control (19), were studied using the precipitate zone assay on the egg yolk agar.Results:No significant difference was found in phospholipase activities between these isolates from normal controls and oral pre-malignant lesions, while the activities of phospholipase of isolates from oral cancers were higher than those of the normal controls.Conclusion:Candida albicansmay play different roles in different manners in these two closely related diseases.

Key words: Candida albicans, phospholipase pre-malignant lesions, squamous cell carcinoma, oral cavity