Abstract:

Objective To determine the incidence of human herpes virus（HHV） 1-4 type including herpes simplex virus type-1（HSV-1）, herpes simplex virus type-2（HSV-2）, varicella-zoster virus（VZV）, Epstein-Barr virus（EBV）in the saliva of human immunodeficiency virus（HIV）-infected patients. Methods The incidence of salivary HSV-1, HSV-2, VZV and EBV from 245 HIV-seropositive individuals and control group was used to investigate by polymerase chain reaction（PCR） or nested PCR. The data was analyzed by SPSS 18.0 statistical software. Results In the 245 HIV-seropositive individuals, the detection rates of HSV-1, HSV-2, VZV, EBV were 29.0%, 3.3%, 4.1%, 82.0%. In the control group, the detection rates of HSV-1, HSV-2, VZV, EBV were 13.3%, 0, 0, 36.7%. Four HHVs were significantly
more prevalent in the salivas of HIV-seropositive persons than those in the control group（P<0.01）. The detection rates of HSV-1, HSV-2, VZV and EBV DNA were no difference between the HIV-positive group with highly active antiretroviral therapy（HAART） and HIV-positive group without HAART（P>0.05）. Conclusion There is a high prevalence of HHV infection in HIV-infected people in Yunnan. The most common virus are EBV, followed by HSV-1, but VZV and HSV-2 are rarely detected. HHV co-infection is also observed.

Key words: human immunodeficiency virus, saliva, highly active antiretroviral therapy, human herpes virus