正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究

doi:10.7518/hxkq.2025.2024288

华西口腔医学杂志 ›› 2025, Vol. 43 ›› Issue (2): 190-196.doi: 10.7518/hxkq.2025.2024288

正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究

吴斌¹(), 胡可欣¹, 杨帆²^,³^,⁴, 卢轶¹, 姜迪¹, 易扬¹, 严斌²^,³^,⁴()

^1.南京林业大学机械电子工程学院，南京210037
^2.南京医科大学附属口腔医院正畸科，南京210029
^3.口腔疾病研究与防治国家级重点实验室培育建设点，南京210029
^4.江苏省口腔转化医学工程研究中心，南京210029

收稿日期:2024-08-06 修回日期:2025-02-16 出版日期:2025-04-01 发布日期:2025-03-25
通讯作者: 严斌 E-mail:wubin@njfu.edu.cn;byan@njmu.edu.cn
作者简介:吴斌，副教授，博士，E-mail：wubin@njfu.edu.cn
基金资助:
国家自然科学基金(82071143);江苏省重点研发计划(BE2022795);江苏省卫生健康委员会重点医学研究项目(ZDA202003);江苏省口腔疾病研究重点实验室研究基金(JSKLOD-KF-1901)

Relationship between fluid shear stress in alveolar bone under orthodontic forces and bone remodeling rate

Wu Bin¹(), Hu Kexin¹, Yang Fan²^,³^,⁴, Lu Yi¹, Jiang Di¹, Yi Yang¹, Yan Bin²^,³^,⁴()

^1.School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China
^2.Dept. of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China
^3.State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing 210029, China
^4.Jiangsu Province Engineering Research Center of Stomatological Translation Medicine, Nanjing 210029, China

Received:2024-08-06 Revised:2025-02-16 Online:2025-04-01 Published:2025-03-25
Contact: Yan Bin E-mail:wubin@njfu.edu.cn;byan@njmu.edu.cn
Supported by:
National Natural Science Foundation of China(82071143);Key Research and Development Program of Jiangsu Province(BE2022795);Key Medical Research Projects of Jiangsu Health Commission(ZDA202003);Jiangsu Provincial Key Laboratory of Oral Diseases Research Fund(JSKLOD-KF-1901)

摘要/Abstract

摘要：

目的探究正畸力作用下不同部位牙槽松质骨内流体流动差异，阐明流体剪切应力与骨改建关系，为解析正畸牙齿移动生物力学机制奠定基础。方法对人牙槽骨样本开展应力松弛试验并拟合Prony级数得到材料参数，建立牙槽骨逆向模型进行流固耦合数值模拟，计算松质骨内流体流动的情况。同时，构建大鼠牙移动模型，探究不同区域骨改建速度的差异。结果人和大鼠牙槽松质骨微观结构分布类似，从根颈向根尖方向骨体积分数和骨小梁厚度逐渐减小，而骨小梁间隙逐渐增大。应力松弛试验下不同牙根层面的松质骨内流体剪切应力分布存在差异，根尖处剪切应力最高（0~0.936 6 Pa）。大鼠牙移动模型表明根尖处呈现更快的骨改建速度。结论流体刺激在牙槽骨改建过程中具有重要影响，会引起牙槽骨结构的变化，最终调控结构改建的速度。

关键词: 牙槽骨, 流固耦合, 流体剪切力, 多孔结构

Abstract:

Objective This study explores the differences in fluid flow within alveolar cancellous bone at various sites under orthodontic forces and elucidates the relationship between fluid shear stress and bone remodeling. These fin-dings lay the groundwork for understanding the biomechanical mechanisms of orthodontic tooth movement. Methods Stress relaxation tests were performed on human alveolar bone samples to determine material parameters by using the Prony series. An inverse model of alveolar bone was then developed for numerical simulations of fluid-structure interactions to calculate fluid flow within cancellous bone. Meanwhile, a rat model of tooth movement was established to investigate variations in bone remodeling speeds across different regions. Results The microstructural distribution of cancellous alveolar bone was similar in humans and rats. The bone volume fraction and trabecular thickness gradually decreased from root cervical region to root apical region, while the trabecular space gradually increased. Under the influence of orthodontic forces, fluid shear stress within cancellous bone showed spatial variability across different levels, with the highest shear stress occurring at the root apical region, ranging from 0 to 0.936 6 Pa. Additionally, the rat model of tooth movement indicated that bone remodeling occurred more rapidly at the root apical region. Conclusion Fluid stimulation has a remarkable effect on al-veolar bone remodeling, causing changes in the structure of alveolar bone and ultimately regulating the speed of structu-ral remodeling.

Key words: alveolar bone, fluid-structure interaction, fluid shear stress, porous structure

中图分类号:

R783.5

吴斌, 胡可欣, 杨帆, 卢轶, 姜迪, 易扬, 严斌. 正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究[J]. 华西口腔医学杂志, 2025, 43(2): 190-196.

Wu Bin, Hu Kexin, Yang Fan, Lu Yi, Jiang Di, Yi Yang, Yan Bin. Relationship between fluid shear stress in alveolar bone under orthodontic forces and bone remodeling rate[J]. West China Journal of Stomatology, 2025, 43(2): 190-196.

图/表 9

图 1

图 2

表 1

图 3

表 2

Prony级数参数

部位	$g 1$	$τ 1$	$g 2$	$τ 2$	$g 3$	$τ 3$	$g 4$	$τ 4$
根颈	0.002?25	0.202?31	0.002?49	5.647?00	0.002?53	5.746?10	0.006?52	115.976?14
根中	0.004?21	0.347?41	0.005?22	3.037?46	0.006?79	18.824?24	0.011?82	142.652?27
根尖	0.003?77	0.521?32	0.006?57	3.889?65	0.007?09	20.039?15	0.011?84	168.032?36

表 2

图 4

表 3

优化反演参数

部位	$g 1$	$τ 1$	$g 2$	$τ 2$	$g 3$	$τ 3$	$g 4$	$τ 4$
根颈	0.002?47	0.347?41	0.003?38	3.037?50	0.003?61	17.942?00	0.008?62	128.530?00
根中	0.004?72	0.436?79	0.005?48	5.873?94	0.007?63	23.375?93	0.014?96	153.924?95
根尖	0.003?46	0.475?32	0.005?85	7.834?65	0.008?58	34.543?27	0.014?79	174.548?69

表 3

图 5

图 6

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部位	BV/TV/%	Tb.Sp/μm	Tb.Th/μm
根颈	31.745±0.624	8.409±0.527	15.654±0.465
根中	27.364±0.317	10.267±0.223	13.193±0.752
根尖	23.989±0.462	12.414±0.625	11.988±0.659

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正畸力下牙槽骨内流体剪切应力与骨改建速度关系研究

Relationship between fluid shear stress in alveolar bone under orthodontic forces and bone remodeling rate

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