L形技术联合浓缩生长因子应用于上颌前牙水平型骨缺损的临床效果观察

doi:10.7518/hxkq.2024.2024268

华西口腔医学杂志 ›› 2025, Vol. 43 ›› Issue (1): 76-83.doi: 10.7518/hxkq.2024.2024268

L形技术联合浓缩生长因子应用于上颌前牙水平型骨缺损的临床效果观察

史芮雯¹^,²(), 杨虎¹, 刘月¹, 史一林¹, 张圣锛¹, 刘煜¹, 宋丰¹, 兰晶¹()

^1.山东大学齐鲁医学院口腔医学院·口腔医院种植科山东省口腔组织再生重点实验室口腔生物材料与组织再生山东省工程研究中心山东省口腔疾病临床医学研究中心，济南 250012
^2.合肥市口腔医院，合肥 230061

收稿日期:2024-07-22 修回日期:2024-09-03 出版日期:2025-02-01 发布日期:2025-01-22
通讯作者: 兰晶 E-mail:srw19980625@163.com;kqlj@sdu.edu.cn
作者简介:史芮雯，住院医师，硕士，E-mail：srw19980625@163.com

L-shape technique with concentrated growth factor for horizontal bone defects in the maxillary anterior region: a clinical and radiographic study

Shi Ruiwen¹^,²(), Yang Hu¹, Liu Yue¹, Shi Yilin¹, Zhang Shengben¹, Liu Yu¹, Song Feng¹, Lan Jing¹()

^1.Dept. of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China
^2.Hefei Stomatological Hospital, Hefei 230061, China

Received:2024-07-22 Revised:2024-09-03 Online:2025-02-01 Published:2025-01-22
Contact: Lan Jing E-mail:srw19980625@163.com;kqlj@sdu.edu.cn

摘要/Abstract

摘要：

目的探讨L形技术联合浓缩生长因子应用于上颌前牙水平型骨缺损的临床效果。方法选择行单颗上颌前牙种植同期植骨的25例患者的25颗种植体为研究对象，据植骨术式的不同，将患者分为试验组（L形技术引导性骨再生术联合浓缩生长因子，11例）、对照组（传统引导性骨再生术联合浓缩生长因子，14例）。对2组患者术后的早期不适、创口愈合、种植体周骨量、种植体周硬组织吸收量、影像灰度值、种植体稳定性等进行对比。结果 2组术后早期不适、创口愈合及术后6个月的种植体稳定性、影像灰度值间的差异均无统计学意义（P>0.05）。术后6个月，试验组的垂直向种植体周骨量大于对照组，差异具有统计学意义（P<0.05）。术后6个月，试验组的水平向种植体周硬组织吸收量大于对照组，差异具有统计学意义（P<0.05）。结论 L形技术联合浓缩生长因子应用于上颌前牙区种植同期垂直向骨增量效果更优，且在种植体稳定性、早期不适及创口愈合方面均可获得良好的临床效果。

关键词: L形技术, 骨缺损, 引导骨再生, 浓缩生长因子, 上颌前牙

Abstract:

Objective To study the clinical effect of the L-shape technique combined with concentrated growth factor on the horizontal bone defects of maxillary anterior teeth. Methods Twenty-five implants from 25 patients who underwent single maxillary anterior tooth implantation with simultaneous bone grafting were selected as the study subjects. Based on the bone grafting techniques, the patients were divided into a test group (L-shaped technique with guided bone regeneration combined with concentrated growth factor, 11 cases) and a control group (traditional guided bone regeneration combined with concentrated growth factor, 14 cases). The early discomfort and wound healing conditions in the two groups at two weeks after surgery were compared. The horizontal bone thickness, vertical bone thickness, and grayscale values in the augmentation area were measured immediately postsurgery and six months after surgery. Implant stability, hard tissue resorption within six months, and grayscale values were compared between the two groups. Results Differences in early discomfort, wound healing, implant stability, and grayscale values between the two groups were not statistically significant (P>0.05). Vertical bone thickness in the test group was significantly better than that in the control group at six months after surgery (P<0.05). The variation in horizontal bone thickness in the test group was significantly higher than that in the control group (P<0.05). Conclusion The application of the L-shape technique with concentrated growth factor for horizontal bone defects in the anterior maxillary area yielded satisfactory short-term results in terms of bone augmentation, early discomfort, wound healing, and implant stability at six months after surgery.

Key words: L-shape technique, bone defect, guided bone regeneration, concentrated growth factor, maxillary anterior

中图分类号:

R783.4

史芮雯, 杨虎, 刘月, 史一林, 张圣锛, 刘煜, 宋丰, 兰晶. L形技术联合浓缩生长因子应用于上颌前牙水平型骨缺损的临床效果观察[J]. 华西口腔医学杂志, 2025, 43(1): 76-83.

Shi Ruiwen, Yang Hu, Liu Yue, Shi Yilin, Zhang Shengben, Liu Yu, Song Feng, Lan Jing. L-shape technique with concentrated growth factor for horizontal bone defects in the maxillary anterior region: a clinical and radiographic study[J]. West China Journal of Stomatology, 2025, 43(1): 76-83.

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项目		试验组	对照组	P值
年龄/岁		54.00±12.32	44.28±13.40	0.075
性别				1.000
	男	7（63.6％）	9（64.3％）
	女	4（36.4％）	5（35.7％）
牙位				0.288
	中切牙	8（72.7％）	13（92.9％）
	侧切牙	3（27.3％）	1（7.1％）
种植体直径/mm				1.000
	3.3	8（72.7％）	11（78.6％）
	4.1	3（27.3％）	3（21.4％）
种植体长度/mm				0.090
	10	10（90.9％）	8（57.1％）
	12	1（9.1％）	6（42.9％）
吸烟				1.000
	是	2（18.2％）	3（21.4％）
	否	9（81.8％）	11（78.6％）
饮酒				0.350
	是	4（36.4％）	2（14.3％）
	否	7（63.6％）	12（85.7％）
糖尿病				0.288
	是	3（27.3％）	1（7.1％）
	否	8（72.7％）	13（92.9％）
愈合基台				0.002
	使用	1（9.1％）	10（71.4%）
	未使用	10（90.9％）	4（28.6%）
临时义齿				0.675
	粘接式义齿	1（9.1％）	1（7.1％）
	隐形义齿	2（18.2％）	1（7.1％）
	未使用	8（72.7％）	12（85.7％）
垂直附加切口设计				0.288
	单侧	3（27.3％）	1（14.3％）
	双侧	8（72.7％）	13（85.7％）

项目	试验组	对照组	t值	P值
肿胀持续时间/d	6.00±3.10	6.86±1.79	0.869	0.394
止痛药量/片	3.36±3.61	3.14±2.14	-0.191	0.851
VAS评分	3.45±1.51	3.43±1.16	-0.049	0.962
创口炎症评分	1.18±0.75	1.64±0.84	1.424	0.168
EHI分级	1.73±0.65	1.79±0.58	0.238	0.814

测量项目	试验组	对照组	t值	P值
HT0	1.96±0.61	1.49±0.99	-1.373	0.121
HT2	2.31±0.55	2.04±0.91	-0.870	0.115
HT4	2.62±0.74	2.34±0.92	-0.811	0.459
VT	1.98±0.96	1.02±0.99	-2.443	0.023*
45-VT	1.84±0.84	1.12±0.84	-2.120	0.045*

项目	试验组	对照组	t值	P值
△HT0	2.78±1.11	1.63±1.23	-2.414	0.024*
△HT2	2.60±1.01	1.51±1.11	-2.556	0.018*
△HT4	2.64±1.21	1.50±1.26	-2.305	0.031*
△VT	1.54±0.91	1.20±1.50	-0.661	0.515
△45-VT	2.14±0.95	1.35±1.24	-1.742	0.095

项目	试验组	对照组	t值	P值
T0灰度值	782.31±212.18	926.83±136.88	2.065	0.050*
T1灰度值	1 411.02±322.31	1 232.25±412.68	-1.216	0.236
T1-T0灰度值变化量	628.71±320.55	305.42±372.59	-2.33	0.029*

L形技术联合浓缩生长因子应用于上颌前牙水平型骨缺损的临床效果观察

L-shape technique with concentrated growth factor for horizontal bone defects in the maxillary anterior region: a clinical and radiographic study

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