可降解镁基金属引导骨再生膜的研究现状与展望

doi:10.7518/hxkq.2024.2024140

华西口腔医学杂志 ›› 2024, Vol. 42 ›› Issue (4): 415-425.doi: 10.7518/hxkq.2024.2024140

• 特约述评 • 下一篇

可降解镁基金属引导骨再生膜的研究现状与展望

陈良伟¹^,²(), 韩建民²^,³(), 郭传瑸¹^,²()

^1.北京大学口腔医学院·口腔医院口腔颌面外科，北京 100081
^2.国家口腔医学中心·国家口腔疾病临床医学研究中心·口腔生物材料和数字诊疗装备国家工程研究中心，北京 100081
^3.北京大学口腔医学院·中心实验室，北京 100081

收稿日期:2024-04-11 修回日期:2024-05-16 出版日期:2024-08-01 发布日期:2024-07-17
通讯作者: 韩建民,郭传瑸 E-mail:chenliangwei@bjmu.edu.cn;hanjianmin@bjmu.edu.cn;guodazuo@sina.com
作者简介:陈良伟，博士，E-mail：chenliangwei@bjmu.edu.cn|韩建民，北京大学口腔医学院中心实验室主任、研究员、副教授、博士研究生导师。现为国家重点研发计划首席科学家，国家高层次人才特殊支持计划青年拔尖人才。一直从事口腔材料的教学、研究开发和评价工作，迄今以第一作者或通讯作者在口腔医学领域国内外期刊上发表论文50余篇，主持或参与制定了20项医药行业标准，作为项目负责人承担国家重点研发计划1项、工信部生物医用材料创新任务揭榜挂帅项目1项、国家自然科学基金3项、国家药品监督管理局课题2项、国内外横向研究课题4项，主持或参与多个省部级课题。|郭传瑸，北京大学口腔医学院口腔颌面外科主任医师、教授、博士生导师。现为中华口腔医学会会长、国家口腔医学质控中心主任、中国医院协会口腔医院分会主任委员、北京市医学会口腔医学分会主任委员、中国卫生信息与健康医疗大数据学会口腔医学专业委员会主任委员、全国医学专业学位研究生教育指导委员会口腔医学分会第一召集人、教育部高等学校口腔医学专业教学指导委员会副主任委员等，为国家卫生健康突出贡献中青年专家，获10余次科技奖励。多年从事口腔颌面肿瘤诊治及口腔癌转移机制研究，数字外科技术在颅底区肿瘤诊治的应用及颅颌面手术机器人的研发。主持完成国家级课题6项、省部级课题5项，主持科技部863和北京市科委资助的颅颌面机器人研发项目，研发出 2个辅助手术机器人样机。迄今共发表论文 213篇（SCI收录 86篇），发明专利3项（实用新型专利1项）。
基金资助:
国家重点研发计划(2021YFC2400703);国家自然科学基金(52171234);北京市科技计划(Z211100002921066);北京大学口腔医院国家临床重点专科科技成果转化支持项目（PKUSS-NKP-Т202104）

Research status and prospects of biodegradable magnesium-based metal-guided bone regeneration membranes

Chen Liangwei¹^,²(), Han Jianmin²^,³(), Guo Chuanbin¹^,²()

^1.Dept. of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China
^2.National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China
^3.Dept. of Key Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China

Received:2024-04-11 Revised:2024-05-16 Online:2024-08-01 Published:2024-07-17
Contact: Han Jianmin,Guo Chuanbin E-mail:chenliangwei@bjmu.edu.cn;hanjianmin@bjmu.edu.cn;guodazuo@sina.com
Supported by:
National Key Research and Development Program of China(2021YFC2400703);National Natural Science Foundation of China(52171234);Beijing Municipal Science and Technology Project(Z211100002921066);Peking University National Clinical Key Specialty Translation Support Project (PKUSSNKP-Т202104)

摘要/Abstract

摘要：

可降解镁基金属引导骨再生（GBR）膜具有良好的机械性能、生物降解性和生物促成骨性能，是治疗颌面部骨缺损的理想植入物。本文对镁基金属引导骨再生膜的现状和未来的研究趋势进行阐述。首先介绍了镁基金属的研究历史及应用领域，随后从镁基金属GBR膜的机械性能、生物相容性和促成骨性能及其机制方面介绍了镁基金属制备GBR膜的应用优势，最后对当前镁基金属GBR膜的局限性及在口腔医学中的应用和展望进行介绍。镁基金属GBR膜在基础和转化研究方面都取得了重要的进展，为治疗口腔颌面部的骨缺损奠定了重要的基础。

关键词: 镁基金属, 引导骨再生膜, 降解, 骨再生, 临床转化

Abstract:

Biodegradable magnesium-based metal-guided bone regeneration (GBR) membranes possess excellent mechanical properties, biodegradability, and osteopromotive capabilities, making them ideal implants for the treatment of maxillofacial bone defects. This review summarizes the current status and future research trends related to magnesium-based GBR membranes. First, the research history and application fields of magnesium-based metals are introduced, and the advantages of the use of magnesium-based materials for GBR membranes, including their mechanical properties, biocompatibility, osteopromotive performance, and underlying mechanisms are discussed. Finally, this review addresses the current limitations of magnesium-based GBR membranes and their applications and prospects in the field of dentistry. In conclusion, considerable advancements have been in fundamental and translational research on magnesium-based GBR membranes, which lays a crucial foundation for the treatment of maxillofacial bone defects.

Key words: magnesium-based metal-guided bone regeneration membrane, degradation, bone regeneration, clinical translation

中图分类号:

R318.08

陈良伟, 韩建民, 郭传瑸. 可降解镁基金属引导骨再生膜的研究现状与展望[J]. 华西口腔医学杂志, 2024, 42(4): 415-425.

Chen Liangwei, Han Jianmin, Guo Chuanbin. Research status and prospects of biodegradable magnesium-based metal-guided bone regeneration membranes[J]. West China Journal of Stomatology, 2024, 42(4): 415-425.

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可降解镁基金属引导骨再生膜的研究现状与展望

Research status and prospects of biodegradable magnesium-based metal-guided bone regeneration membranes

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