低强度脉冲超声促进骨组织再生相关机制的研究进展

doi:10.7518/hxkq.2020.05.017

摘要/Abstract

摘要：

低强度脉冲超声（LIPUS）是临床常见的物理治疗手段之一,可用于促进骨折愈合以及治疗陈旧性骨不连。局部血管、神经和骨组织密切相关、互相影响,是骨组织再生的重要影响因素。近年来越来越多的数据表明LIPUS不仅能作用于成骨细胞、破骨细胞、间充质干细胞等发挥促成骨效应,还可通过其对血管、神经的作用对骨组织愈合与再生产生一定的积极影响。本文从LIPUS对骨组织的直接作用和LIPUS通过促进血管及神经再生对骨组织的间接作用2个方面,就LIPUS在骨组织再生方面相关分子机制的最新研究进展作一综述,为LIPUS治疗骨相关疾病提供新的思路。

关键词: 低强度脉冲超声, 骨组织再生, 血管生成, 神经再生

Abstract:

Low-intensity pulsed ultrasound (LIPUS) is a common physical therapy to accelerate the healing of bone fracture and treat delayed union of bone fracture. Vessels, nerves, and bone tissue are essential constituents of bone system. Recently, increasing evidence has been revealed that LIPUS can not only promote bone regeneration by directly regulating osteoblasts, osteoblasts, mesenchymal stem cells, but also have a positive impact on the repair of bone healing through vessels and nerves. Thus, we reviewed and summarized the latest published literature about the molecular mechanism for the effects of LIPUS on bone regeneration, which might offer a promising therapy for bone-related diseases.

Key words: low-intensity pulsed ultrasound, bone regeneration, angiogenesis, nerve regeneration

中图分类号:

姜懿轩, 宫苹, 张亮. 低强度脉冲超声促进骨组织再生相关机制的研究进展[J]. 华西口腔医学杂志, 2020, 38(5): 571-575.

Jiang Yixuan, Gong Ping, Zhang Liang. A review of mechanisms by which low-intensity pulsed ultrasound affects bone regeneration[J]. West China Journal of Stomatology, 2020, 38(5): 571-575.

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