韦荣球菌与口腔疾病的研究进展

doi:10.7518/hxkq.2020.05.018

摘要/Abstract

摘要：

韦荣球菌是口腔生物膜的早期定植菌之一,高丰度分布于口腔微生态中。目前在口腔中已检出7种韦荣球菌,其在不同部位、不同患者口腔中存在分布差异。近年来研究发现,韦荣球菌与口腔疾病的关系密切,韦荣球菌有助于变异链球菌的黏附且能分解链球菌代谢产生的乳酸,是被公认的致龋因素之一;韦荣球菌为牙龈卟啉单胞菌提供黏附位点,并可通过促进免疫反应参与牙周病的发生发展;韦荣球菌脂多糖的致病性及代谢产生H₂S也与牙髓及根尖周病、口臭等相关。韦荣球菌与疾病的相关性已有研究进行阐释,与相关致病菌的作用机制也有一定进展,但其影响口腔疾病发生发展的分子机制仍不明确,本文就韦荣球菌与龋病、牙周病等口腔感染性疾病的研究进展作一综述。

关键词: 韦荣球菌, 龋病, 牙周病, 口腔疾病

Abstract:

Veillonella species, known as the early colonizer of oral biofilm, are prevalent in oral microbiota. Seven Veillonella species have been isolated from oral cavity. Their distribution varies not only with different people but also with different sites in the oral cavity. Oral Veillonella are associated with oral diseases. They contribute to the adhesion of Streptococcus mutans and consume the lactate generated by streptococci. Veillonella species play an important role in the occurrence and development of periodontal diseases by providing adhesion sites for Porphyromonas gingivalis and boosting immune responses. The production of lipopolysaccharide and H₂S is related to other oral diseases, such as pulpitis, periapical periodontitis, and halitosis. Several studies have been conducted on the relationship between Veillonella and oral diseases and the interaction between Veillonella and other pathological microorganisms, but limited knowledge is available at the molecular level. This article reviews the research progress in the relationship between Veillonella and oral infectious diseases, such as dental caries and periodontal diseases.

Key words: Veillonella, dental caries, periodontal diseases, oral diseases

中图分类号:

罗瑜雪, 孙蔓琳, 施培磊, 刘盼, 陈艺尹, 彭显. 韦荣球菌与口腔疾病的研究进展[J]. 华西口腔医学杂志, 2020, 38(5): 576-582.

Luo Yuxue, Sun Manlin, Shi Peilei, Liu Pan, Chen Yiyin, Peng Xian. Research progress in the relationship between Veillonella and oral diseases[J]. West China Journal of Stomatology, 2020, 38(5): 576-582.

图/表 2

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