关键词: 氨基胍, 一氧化氮合酶, 面瘫, 面神经, 免疫组织化学, 大鼠

Abstract:

Objective　To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.Methods　Asmall dose of aminoguanidine were intraperitoneally injected into rats before and after facial paralysis. The facial nerve and surrounding tissues were cut at different time point. Immunohisto- chemical ABC method was used to study the changes of NOS expression in facial nerve and surrounding tissues.Results　The in- ducible NOS immunoreactivity was obvious inhibited in the facial nerve and surrounding tissues in aminoguanidine group.Conclu- sion　Aminoguanidine chronic treatment can obvious inhibit the inducible NOS expression in the facial nerve and surrounding tis- sues. Aminoguanidine can improve the regeneration of facial nerve and the recovery of traumatic tissues.

Key words: aminoguanidine, nitric oxide synthase, facial paralysis, facial nerve, immunohistochemistry, rat