S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义

doi:10.3969/j.issn.1000-1182.2011.06.011

华西口腔医学杂志

S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义

赵业1 郑亚鸽2 张丽慧3 姚甜3 吴兰雁3

1.大同市第三人民医院口腔科，大同037008； 2.四川省双流县妇幼保健院口腔科，成都610200； 3.四川大学华西口腔医院病理科，成都610041

收稿日期:2011-12-25 修回日期:2011-12-25 出版日期:2011-12-20 发布日期:2011-12-20
通讯作者: 吴兰雁，Tel：13568905320
作者简介:赵业（1976—），男，山西人，主治医师，硕士

The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis

Zhao Ye1, Zheng Yage2, Zhang Lihui3, Yao Tian3, Wu Lanyan3

1. Dept. of Stomatology, Datong No.3 People’s Hospital, Datong 037008, China; 2. Dept. of Stomatology, Shuangliu Maternal and Child Health Hospital of Sichuan Province, Chengdu 610200, China; 3. Dept. of Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China

Received:2011-12-25 Revised:2011-12-25 Online:2011-12-20 Published:2011-12-20
Contact: Wu Lanyan，Tel：13568905320

摘要/Abstract

摘要：

目的对口腔朗格汉斯细胞组织细胞增生症（LCH）病例进行临床病理回顾性研究及多种免疫表型检测，观察该类疾病的临床病理特征，并对其诊断、鉴别诊断等进行探讨。方法选择原病理诊断为LCH的29例患者为研究对象，分析其临床病理特点；采用链亲和素-生物素-过氧化物酶（SP）法和Elivison二步法检测S-100蛋白、CD1a、CD83及Ki-67在LCH中的表达情况，观察其免疫组织化学结果并进行统计学分析。结果29例LCH中有5例S-100蛋白、CD1a检测为阴性，排除LCH诊断。在24例LCH中，男性15例，女性9例；患者中位年龄为7.50岁；14例发生于下颌骨，5例发生于上颌骨，5例发生于上下颌骨；按照Bartnick分类，Ⅰ类9例，Ⅱ类13例，Ⅲ类2例；S-100蛋白、CD1a均为阳性表达；颌面部单发骨病损与侵及软组织的颌面部病损相比，Ki-67阳性率较低，而CD83阳性率较高。结论S-100蛋白、CD1a对于LCH的诊断具有重要意义。颌面部单发的骨LCH可能具有较低的增殖活性，并处于较高的成熟状态；侵及软组织的颌面部LCH可能具有较高的增殖活性，并处于较低的成熟状态。

关键词: 朗格汉斯细胞组织细胞增生症, S-100蛋白, CD1a, CD83, Ki-67

Abstract:

Objective To study clinicopathological features, diagnosis, differential diagnosis of oral Langerhans cell histiocytosis（LCH）, retrospective clinicopathologic study was carried on and a variety of immune phenotype were de -tected. Methods The clinicopathological features of 29 cases of oral LCH were analyzed. The immunohistochemical staining of S-100 protein, CD1a, CD83 and Ki-67 were used in above cases by immunohistochemical streptavidinbiotin peroxidase（SP） and Elivison two-step method. Statistical analysis was adopted for the results. Results Of the 29 cases of LCH, the expression of S-100 protein and CD1a were positive in 24 cases and negative in 5 cases, so 5 cases were excluded from the diagnosis of LCH. Among 24 cases of LCH, 15 patients were male and 9 were female. The median age was 7.50 years. 14 lesions were in the mandible, 5 were in the maxilla and 5 involved the mandible and maxilla. 9 cases were in stage Ⅰ, 13 in stage Ⅱ and 2 in stage Ⅲ, according to Bartnick classification. Immunohistochemistry showed all 24 cases staining for S-100 protein and CD1a were positive. Comparing with maxillofacial lesions involved soft tissue, Ki-67 positive rate was lower and CD83 positive rate was higher in maxillofacial single
bone lesion. Conclusion The immunohistochemical staining of S-100 protein and CD1a are important for the diagnosis
of LCH. Maxillofacial bone single LCH might have lower proliferative activity and a higher state of maturity. Maxillofacial
LCH involved soft tissue might have a higher proliferative activity and a lower state of maturity.

Key words: Langerhans cell histiocytosis, S-100 protein, CD1a, CD83, Ki-67

赵业郑亚鸽张丽慧姚甜吴兰雁. S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义[J]. 华西口腔医学杂志, doi: 10.3969/j.issn.1000-1182.2011.06.011.

Zhao Ye1, Zheng Yage2, Zhang Lihui3, Yao Tian3, Wu Lanyan3. The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis[J]. West China Journal of Stomatology, doi: 10.3969/j.issn.1000-1182.2011.06.011.

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S-100蛋白、CD1a、CD83及Ki-67在口腔朗格汉斯细胞组织细胞增生症中的表达及意义

The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis

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