关键词: 腺病毒为载体的单纯疱疹病毒胸苷激酶/更昔洛韦系统, 光动力, 血卟啉衍生物, 恶性肿瘤

Abstract:

Objective To evaluate the method of adenovirus vector-mediated herpes simplex virus-thymidine kinase gene（ADV-TK）/ganciclovir（GCV） system and photodynamic therapy（PDT） for treating the oral malignant tumor. Methods Ten patients who were suffering from oral malignant tumor of the different positions were selected, and injected with the hematoporphyrin derivative（HPD）, irradiated by picking the corresponding laser frequency, and injected the ADV-TK gene into the tumor body and periphery. By the imaging and the hemodynamics analysis, the clinical efficacy after infusing vein with GCV was assessed. Results After the combination method treatments, patients’tumors appeared clear shrinkage or complete extinction. There was obvious fall of the blood flow volume in the tumor body. Imaging results showed significantly differences. So it was a perfect and effective treatment. Conclusion There are many advantages to apply the ADV-TK/GCV system and PDT treatment on the oral malignant tumor, minimal side effects and greater clinical security. It is a safe and credible therapy which can be offered for curing the oral malignant tumor systematically.

Key words: adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system, photodynamic therapy, hematoporphyrin derivative； malignant tumor