West China Journal of Stomatology

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The expression of vascular endothelial growth factor-C in oral squamous cell carcinoma and its associations with angiogenesis, lymphangiogenesis and lymph node metastasis

CHEN Si-xiu, LI Xiao-yu, KONG Xiang-li, FENG Yun   

  1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
  • Received:2010-06-25 Revised:2010-06-25 Online:2010-06-20 Published:2010-06-20
  • Contact: LI Xiao-yu,Tel:13608033538
  • About author:陈思秀(1960—),女,四川人,助理实验师
  • Supported by:



Objective To study the expression of vascular endothelial growth factor-C(VEGF-C) in oral squamous cell carcinoma(OSCC) and its relation to angiogenesis, lymphangiogenesis, as well as lymph node metastasis. Methods Sixty-seven archival specimens from patients with oral squamous cell carcinoma were investigated, whose clinicopathologic data were completely conserved. Immunohistochemical staining was performed to detect the expression of VEGF-C, microvessel density(MVD), lymphatic vessel density(LVD). The correlations between VEGF-C expression and MVD, LVD, as well as other clinicopathological features were measured. Results Although no correlation between VEGF-C expression and tumor location, histological grade, or gender of the patients was observed(P>0.05), OSCC patients with more advanced clinical stages and lymph node metastasis were prone to have high expression of VEGF-C(P=0.015 and P<0.001, respectively). Cases with high-expression of VEGF-C also showed significantly more often higher LVD(P=0.001) but not MVD(P=0.125). In addition, cases with lymph node involvement presented higher LVD than other cases(P=0.026). Conclusion VEGF-C may promote lymph node metastasis by inducing lymphangiogenesis in OSCC.

Key words: oral squamous cell carcinoma, vascular endothelial growth factor -C, micro vessel density, lymphatic vessel density