West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (5): 501-509.doi: 10.7518/hxkq.2021.05.002

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The investigation of energy metabolism in osteoblasts and osteoclasts

Shi Yu.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-25 Revised:2021-07-08 Online:2021-10-01 Published:2021-10-11
  • Contact: Shi Yu. E-mail:yushi1105@163.com
  • Supported by:
    The National Natural Science Foundation of China(82071091);Sichuan Science and Technology Program(2020ZYD001);The Scientific Research Foundation for Recruited Talents-West China Hospital of Stomatology, Sichuan University(QDJF2019-2);Correspondence: Shi Yu, E-mail: yushi1105@163.com


The maintenance of bone homeostasis is critical for bone health. It is vulnerable to cause bone loss, even severely osteoporosis when the balance between bone formation and absorption is interrupted. Growing evidence has shown that energy metabolism disorders, such as abnormal glucose metabolism, irregular amino acid metabolism, and aberrant lipid metabolism, can damage bone homeostasis, causing or exacerbating bone mass loss and osteoporosis-related fractures. Here, we summarize the studies of energy metabolism in osteoblasts and osteoclasts and provide a better appreciation of how energy metabolism, especially glucose metabolism maintains bone homeostasis. With this knowledge, new avenues will be unraveled to understand and cue bone-related diseases such as osteoporosis.

Key words: energy metabolism, glucose metabolism, osteoblast, osteoclast, osteoporosis

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