华西口腔医学杂志 ›› 2021, Vol. 39 ›› Issue (1): 108-114.doi: 10.7518/hxkq.2021.01.017

• 综述 • 上一篇    下一篇

软骨干细胞标记及诱导分化的研究进展

牟婷琛1(), 冯剑颖2()   

  1. 1.台州市中心医院(台州学院附属医院)口腔科,台州 318000
    2.浙江中医药大学口腔医学院,杭州 310053
  • 收稿日期:2019-04-13 修回日期:2020-06-20 出版日期:2021-02-01 发布日期:2021-03-02
  • 通讯作者: 冯剑颖 E-mail:389385230@qq.com;twohorsejy@163.com
  • 作者简介:牟婷琛,住院医师,硕士,E-mail:389385230@qq.com
  • 基金资助:
    国家自然科学基金(81200802);浙江省自然科学基金(Y2111273)

Research advances in cartilage stem cells markers and induced differentiation

Mou Tingchen1(), Feng Jianying2()   

  1. 1.Dept. of Stomatological, Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, China
    2.College of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • Received:2019-04-13 Revised:2020-06-20 Online:2021-02-01 Published:2021-03-02
  • Contact: Feng Jianying E-mail:389385230@qq.com;twohorsejy@163.com
  • Supported by:
    The National Natural Science Foundation of China(81200802);Zhejiang Provincial Natural Science Foundation(Y2111273)

摘要:

软骨干细胞是关节软骨中具有自我增殖、表面抗原表达特性及多向分化潜能的细胞,作为一种理想的干细胞来源,在干细胞治疗中有良好的应用前景。本文就软骨干细胞的标记、软骨分化信号通路、骨关节炎的临床治疗方法等研究进展进行综述。

关键词: 软骨干细胞, 标记物, 软骨成骨, 骨关节炎

Abstract:

Cartilage stem cells (CSCs) are cells that self-proliferate, have surface antigen expression, and have multidirectional differentiation potential in the articular cartilage. CSCs, as an ideal source of stem cells, has a good application prospect in stem cell therapy. This article reviews the CSCs markers, cartilage differentiation signaling pathway, and clinical treatment of osteoarthritis.

Key words: cartilage stem cells, marker, cartilage ossification, osteoarthritis

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