华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (1): 80-85.doi: 10.7518/hxkq.2020.01.014
收稿日期:
2018-10-15
修回日期:
2019-09-27
出版日期:
2020-02-01
发布日期:
2020-02-06
通讯作者:
尚政军
E-mail:shangzhengjun@whu.edu.cn
作者简介:
许智,主治医师,博士,E-mail: 2017xh0090@hust.edu.cn
基金资助:
Xu Zhi1,Lü Fengyuan2,Jiang Erhui3,Zhao Xiaoping2,Shang Zhengjun3()
Received:
2018-10-15
Revised:
2019-09-27
Online:
2020-02-01
Published:
2020-02-06
Contact:
Zhengjun Shang
E-mail:shangzhengjun@whu.edu.cn
Supported by:
摘要:
槟榔作为一级致癌物,其与口腔癌的关系受到广泛关注。活性氧(ROS)及自噬水平与肿瘤的发生发展密切相关,研究发现槟榔可诱发细胞内ROS及自噬水平变化。本文结合相关研究进展,对槟榔、细胞内ROS以及自噬之间的关系进行综述。
中图分类号:
许智,吕逢源,姜二辉,赵小平,尚政军. 槟榔与细胞内活性氧及自噬的关系[J]. 华西口腔医学杂志, 2020, 38(1): 80-85.
Xu Zhi,Lü Fengyuan,Jiang Erhui,Zhao Xiaoping,Shang Zhengjun. Relationship among areca nut, intracellular reactive oxygen species, and autophagy[J]. West China Journal of Stomatology, 2020, 38(1): 80-85.
[1] | Warnakulasuriya S . Global epidemiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009,45(4/5):309-316. |
[2] | Zhang XL, Reichart PA . A review of betel quid chewing, oral cancer and precancer in Mainland China[J]. Oral Oncol, 2007,43(5):424-430. |
[3] | 高义军, 彭海艳, 尹晓敏 , 等. 湖南省娄底市城区中小学生嚼槟榔情况调查[J]. 中华口腔医学杂志, 2009,44(11):686-689. |
Gao YJ, Peng HY, Yin XM , et al. Epidemiological study of betel nut chewing among elementary and middle school students in Loudi city, Hunan Province[J]. Chin J Stomatol, 2009,44(11):686-689. | |
[4] | Petti S . Lifestyle risk factors for oral cancer[J]. Oral Oncol, 2009,45(4/5):340-350. |
[5] | 张春江, 吕飞杰, 陶海腾 . 槟榔活性成分及其功能作用的研究进展[J]. 中国食物与营养, 2008(6):50-53. |
Zhang CJ, Lü FJ, Tao HT . Advances in studies on active ingredients and their functions of areca nut[J]. Food Nutrit China, 2008(6):50-53. | |
[6] | 牟肖男, 杨文强, 王文婧 , 等. 槟榔的化学成分[J]. 暨南大学学报(自然科学与医学版), 2014,35(1):56-60. |
Mu XN, Yang WQ, Wang WJ , et al. Chemical constituents from the fruits of Areca catechu[J]. J Jinan Univ (Nat Sci Med Ed), 2014,35(1):56-60. | |
[7] | 郭峰, 翦新春, 周晌辉 , 等. 口腔黏膜下纤维性变癌变的病理及临床生物学行为回顾性研究[J]. 中华口腔医学杂志, 2011,46(8):494-497. |
Guo F, Jian XC, Zhou SH , et al. A retrospective study of oral squamous cell carcinomas originated from oral submucous fibrosis[J]. Chin J Stomatol, 2011,46(8):494-497. | |
[8] | Li L, Tan J, Miao Y , et al. ROS and autophagy: interactions and molecular regulatory mechanisms[J]. Cell Mol Neurobiol, 2015,35(5):615-621. |
[9] | Rahal A, Kumar A, Singh V , et al. Oxidative stress, prooxidants, and antioxidants: the interplay[J]. Biomed Res Int, 2014,2014:761264. |
[10] | Mizushima N, Levine B, Cuervo AM , et al. Autophagy fights disease through cellular self-digestion[J]. Nature, 2008,451(7182):1069-1075. |
[11] | Cecconi F, Levine B . The role of autophagy in mammalian development: cell makeover rather than cell death[J]. Dev Cell, 2008,15(3):344-357. |
[12] | Dewaele M, Maes H, Agostinis P . ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy[J]. Autophagy, 2010,6(7):838-854. |
[13] | Cook JA, Gius D, Wink DA , et al. Oxidative stress, redox, and the tumor microenvironment[J]. Semin Radiat Oncol, 2004,14(3):259-266. |
[14] | Esposito F, Ammendola R, Faraonio R , et al. Redox control of signal transduction, gene expression and cellular senescence[J]. Neurochem Res, 2004,29(3):617-628. |
[15] | Reczek CR, Chandel NS . ROS-dependent signal transduction[J]. Curr Opin Cell Biol, 2015,33:8-13. |
[16] | Balaban RS, Nemoto S, Finkel T . Mitochondria, oxidants, and aging[J]. Cell, 2005,120(4):483-495. |
[17] | Goetz ME, Luch A . Reactive species: a cell damaging rout assisting to chemical carcinogens[J]. Cancer Lett, 2008,266(1):73-83. |
[18] | Wu WS . The signaling mechanism of ROS in tumor progression[J]. Cancer Metastasis Rev, 2006,25(4):695-705. |
[19] | Hayes JD , McMahon M. The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer[J]. Mol Cell, 2006,21(6):732-734. |
[20] | Nioi P, Nguyen T . A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity[J]. Biochem Biophys Res Commun, 2007,362(4):816-821. |
[21] | Ohta T, Iijima K, Miyamoto M , et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth[J]. Cancer Res, 2008,68(5):1303-1309. |
[22] | Lin WJ, Jiang RS, Wu SH , et al. Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study[J]. J Oncol, 2011,2011:525976. |
[23] | Chen CL, Chi CW, Liu TY . Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo[J]. J Toxicol Environ Health A, 2002,65(3/4):327-336. |
[24] | Diakowska D, Lewandowski A, Kopeć W , et al. Oxidative DNA damage and total antioxidant status in serum of patients with esophageal squamous cell carcinoma[J]. Hepatogastroenterology, 2007,54(78):1701-1704. |
[25] | Tanaka H, Fujita N, Sugimoto R , et al. Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C[J]. Br J Cancer, 2008,98(3):580-586. |
[26] | Lin MH, Liu SY, Liu YC . Autophagy induction by a natural ingredient of areca nut[J]. Autophagy, 2008,4(7):967-968. |
[27] | Lin MH, Hsieh WF, Chiang WF , et al. Autophagy induction by the 30-100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species[J]. Oral Oncol, 2010,46(11):822-828. |
[28] | Thangjam GS, Kondaiah P . Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes[J]. J Periodont Res, 2009,44(5):673-682. |
[29] | Illeperuma RP, Kim DK, Park YJ , et al. Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes[J]. Int J Cancer, 2015,137(11):2545-2557. |
[30] | Scherz-Shouval R, Elazar Z . Regulation of autophagy by ROS: physiology and pathology[J]. Trends Biochem Sci, 2011,36(1):30-38. |
[31] | Ji WT, Yang SR, Chen JY , et al. Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma[J]. Cancer Sci, 2012,103(7):1221-1229. |
[32] | Codogno P, Meijer AJ . Autophagy and signaling: their role in cell survival and cell death[J]. Cell Death Differ, 2005,12(Suppl 2):1509-1518. |
[33] | Sannigrahi MK, Singh V, Sharma R , et al. Role of autophagy in head and neck cancer and therapeutic resistance[J]. Oral Dis, 2015,21(3):283-291. |
[34] | Showkat M, Beigh MA , Andrabi KI. mTOR signaling in protein translation regulation: implications in cancer genesis and therapeutic interventions[J]. Mol Biol Int, 2014,2014:686984. |
[35] | Trivedy C, Baldwin D, Warnakulasuriya S , et al. Copper content in areca catechu (betel nut) products and oral submucous fibrosis[J]. Lancet, 1997,349(9063):1447. |
[36] | Khan I, Pant I, Narra S , et al. Epithelial atrophy in oral submucous fibrosis is mediated by copper (Ⅱ) and arecoline of areca nut[J]. J Cell Mol Med, 2015,19(10):2397-2412. |
[37] | 中华口腔医学会口腔黏膜病专业委员会. 口腔黏膜下纤维性变的诊断标准(试行稿)[J]. 中华口腔医学杂志, 2009,44(3):130-131. |
Society of Oral Medicine, Chinese Stomatological Association. Diagnosis criteria of oral submucous fibrosis (draft)[J]. Chin J Stomatol, 2009,44(3):130-131. | |
[38] | 彭解英, 孟庆玉, 李继佳 . 口腔黏膜下纤维性变的诊断研究进展[J]. 中国实用口腔科杂志, 2011,4(2):72-75. |
Peng JY, Meng QY, Li JJ . Diagnosis of oral submucous fibrosis[J]. Chin J PractStomatol, 2011,4(2):72-75. | |
[39] | Chang MC, Chiang CP, Lin CL , et al. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit[J]. Oral Oncol, 2005,41(8):757-775. |
[40] | Chang LY, Wan HC, Lai YL , et al. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress[J]. Arch Oral Biol, 2013,58(10):1523-1531. |
[41] | Chang LY, Wan HC, Lai YL , et al. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells[J]. J Periodontal Res, 2009,44(2):175-183. |
[42] | Angadi PV, Rekha KP . Oral submucous fibrosis: a clinicopathologic review of 205 cases in Indians[J]. Oral Maxillofac Surg, 2011,15(1):15-19. |
[43] | Chaturvedi P, Vaishampayan SS, Nair S , et al. Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease[J]. Head Neck, 2013,35(10):1404-1409. |
[44] | Murgod VV, Kale AD, Angadi PV , et al. Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma[J]. J Oral Sci, 2014,56(2):173-178. |
[45] | Murgod VV, Kale AD, Angadi PV , et al. Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma[J]. J Oral Sci, 2014,56(2):173-178. |
[46] | Hung TC, Huang LW, Su SJ , et al. Hemeoxygenase-1 expression in response to arecoline-induced oxidative stress in human umbilical vein endothelial cells[J]. Int J Cardiol, 2011,151(2):187-194. |
[47] | Ullah M, Cox S, Kelly E , et al. Arecoline is cytotoxic for human endothelial cells[J]. J Oral Pathol Med, 2014,43(10):761-769. |
[48] | Qin AP, Liu CF, Qin YY , et al. Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia[J]. Autophagy, 2010,6(6):738-753. |
[49] | Janku F, McConkey DJ, Hong DS , et al. Autophagy as a target for anticancer therapy[J]. Nat Rev Clin Oncol, 2011,8(9):528-539. |
[50] | O’Donovan TR, O’Sullivan GC, McKenna SL . Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics[J]. Autophagy, 2011,7(5):509-524. |
[51] | Lefort S, Joffre C, Kieffer Y , et al. Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers[J]. Autophagy, 2014,10(12):2122-2142. |
[52] | Yen CY, Lin MH, Liu SY , et al. Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction[J]. Oral Oncol, 2011,47(5):345-351. |
[53] | Chang BE, Liao MH, Kuo MY , et al. Developmental toxicity of arecoline, the major alkaloid in betel nuts, in zebrafish embryos[J]. Birth Defects Res Part A Clin Mol Teratol, 2004,70(1):28-36. |
[54] | Xu Z, Huang CM, Shao Z , et al. Autophagy induced by areca nut extract contributes to decreasing cisplatin toxicity in oral squamous cell carcinoma cells: roles of reactive oxygen species/AMPK signaling[J]. Int J Mol Sci, 2017,18(3):524. |
[55] | Yeh CY, Chen HM, Chang MC , et al. Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components[J]. J Formos Med Assoc, 2016,115(2):108-112. |
[56] | Yen CY, Chiang WF, Liu SY , et al. Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity[J]. J Oral Pathol Med, 2014,43(2):91-96. |
[57] | Yen CY, Chiang WF, Liu SY , et al. Impacts of autophagy-inducing ingredient of areca nut on tumor cells[J]. PLoS One, 2015,10(5):e0128011. |
[58] | Liu SY, Lin MH, Hsu YR , et al. Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy: a pilot study[J]. J Biomed Sci, 2008,15(6):823-831. |
[59] | Sakakura K, Takahashi H, Kaira K , et al. Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma[J]. Cancer Sci, 2015,106(1):1-8. |
[1] | 晚晓芳, 何海燕, 吕佳岭, 伍宇婕, 钟冠男, 徐晓梅. 周期性张应力作用下Hippo-YAP信号通路调控人牙周膜细胞自噬[J]. 华西口腔医学杂志, 2023, 41(3): 260-268. |
[2] | 范智博, 金珂, 李胜鸿, 徐洁, 徐晓梅. 饥饿条件下活性氧通过PINK1/Parkin通路调控人牙周膜细胞的线粒体自噬[J]. 华西口腔医学杂志, 2022, 40(6): 645-653. |
[3] | 卢倩, 郭柳媚, 毕小琴. 口腔癌患者术后吞咽障碍危险因素的系统评价[J]. 华西口腔医学杂志, 2022, 40(3): 328-334. |
[4] | 李若焓, 黄颖昭, 廖乃麟, 吴沉洲, 李一. 口腔癌细胞通过传递性内质网应激影响胰岛β细胞功能的初探[J]. 华西口腔医学杂志, 2022, 40(1): 22-31. |
[5] | 贾美娥, 李志勇, 徐凯, 王怡衡, 于菲, 何祥一. 口腔癌细胞Cal27外泌体对人正常牙龈成纤维细胞的生物学作用[J]. 华西口腔医学杂志, 2021, 39(3): 313-319. |
[6] | 郭锦材, 谢辉, 吴昊, 童铁军. 姜黄素治疗口腔黏膜下纤维性变有效性的Meta分析[J]. 华西口腔医学杂志, 2021, 39(2): 195-202. |
[7] | 刘伟, 李春洁, 李龙江. 口腔癌颌骨侵犯的分子机制研究进展[J]. 华西口腔医学杂志, 2021, 39(2): 221-226. |
[8] | 张东升, 郑家伟, 张陈平, 蔡志刚, 李龙江, 廖贵清, 尚政军, 孙沫逸, 韩正学, 尚伟, 孟箭, 龚忠诚, 黄圣运. 口腔癌合并全身系统性疾病患者的多学科协作诊疗模式专家共识[J]. 华西口腔医学杂志, 2020, 38(6): 603-615. |
[9] | 刘欣辰, 卢金金, 陈雨蒙, 邱滢, 郑梦丹, 王梓霖, 李祥伟. 自噬在间充质干细胞自我更新和分化中作用的研究进展[J]. 华西口腔医学杂志, 2020, 38(6): 704-707. |
[10] | 廖敏, 程磊, 周学东, 任彪. 白色念珠菌对口腔黏膜疾病恶性转化作用的研究进展[J]. 华西口腔医学杂志, 2020, 38(4): 431-437. |
[11] | 程俊鑫, 白贺天, 常治楠, 李敬, 陈谦明. 口腔黏膜癌前病变和口腔癌动物模型的研究进展[J]. 华西口腔医学杂志, 2020, 38(2): 198-204. |
[12] | 赵军方,查治安,谢卫红,王海斌,李新明,孙强,孙明磊. 长链非编码RNA H19对口腔癌细胞的迁移和侵袭的影响以及分子机制[J]. 华西口腔医学杂志, 2019, 37(4): 378-383. |
[13] | 莫龙义,贾小玥,刘程程,周学东,徐欣. 细胞自噬在牙周炎中的作用与机制[J]. 华西口腔医学杂志, 2019, 37(4): 422-427. |
[14] | 杨博,符梦凡,唐瞻贵. 槟榔碱及机械刺激构建大鼠口腔黏膜下纤维化模型[J]. 华西口腔医学杂志, 2019, 37(3): 260-264. |
[15] | 吕佳岭,徐洁,曾锦,党海霞,余京泓,赵娴,徐晓梅. 正畸牙压力区牙周膜细胞自噬相关蛋白Beclin-1与微管相关蛋白2轻链3的表达[J]. 华西口腔医学杂志, 2019, 37(2): 168-173. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||