关键词: 维甲酸相关核孤儿受体&gamma, t, 4-1BB, 4-1BBL, 口腔扁平苔藓

Abstract:

 Objective  To investigate the expression of the peripheral blood retinoid-related orphan receptor γt（RORγt） and 4-1BB/4-1BBL mRNA in oral lichen planus（OLP） patients. Methods  The expression levels of peripheral blood’RORγt mRNA and 4-1BB/4-1BBL mRNA of 30 samples of OLP patients and 30 cases of healthy human were detected using real-time fluorescent quantitative-polymerase chain reaction（FQ-PCR） technology. Results  In the OLP group, the expression level of RORγt, 4-1BB, 4-1BBL mRNA were higher than those in the control group
（P<0.05）. After the conversion of the 2-ΔΔCT, the expression levels of three kinds of mRNA in the OLP group were 3.087, 3.320 and 4.005 times of the control group respectively. In the OLP group, the expression levels of RORγt mRNA and 4-1BB mRNA had no obvious correlation（P>0.05）, the expression levels of 4-1BB and 4-1BBL mRNA had a positive correlation（r=0.455 0, P<0.05）. Conclusion  The abnormal expression of RORγt, 4-1BB and 4-1BBL mRNA may play certain roles in the pathogenesis of OLP.

Key words:  retinoid-related orphan receptor γt, 4-1BB, 4-1BBL, oral lichen planus