West China Journal of Stomatology ›› 2024, Vol. 42 ›› Issue (2): 181-191.doi: 10.7518/hxkq.2024.2023285
• Basic Research • Previous Articles Next Articles
Sun Jinmeng1(), Zhang Ying1, Zheng Zejun1, Ding Xiaoling2, Sun Minmin1(), Ding Gang1()
Received:
2023-08-31
Revised:
2024-01-17
Online:
2024-04-01
Published:
2024-03-26
Contact:
Sun Minmin,Ding Gang
E-mail:sunjinmeng07@163.com;sunminmin@wfmc.edu.cn;dinggang@wfmc.edu.cn
Supported by:
CLC Number:
Sun Jinmeng, Zhang Ying, Zheng Zejun, Ding Xiaoling, Sun Minmin, Ding Gang. Potential mechanism of ginseng in the treatment of periodontitis based on network pharmacology and molecular docking[J]. West China Journal of Stomatology, 2024, 42(2): 181-191.
Add to citation manager EndNote|Ris|BibTeX
Tab 1
Information of active ingredients of ginseng
分子身份标识号码 | 活性成分 | OB/% | DL/% |
---|---|---|---|
MOL002879 | Diop | 43.59 | 0.39 |
MOL000449 | Stigmasterol | 43.83 | 0.76 |
MOL000358 | beta-sitosterol | 36.91 | 0.75 |
MOL003648 | Inermin | 65.83 | 0.54 |
MOL000422 | kaempferol | 41.88 | 0.24 |
MOL004492 | Chrysanthemaxanthin | 38.72 | 0.58 |
MOL005308 | Aposiopolamine | 66.65 | 0.22 |
MOL005314 | Celabenzine | 101.88 | 0.49 |
MOL005317 | Deoxyharringtonine | 39.27 | 0.81 |
MOL005318 | Dianthramine | 40.45 | 0.2 |
MOL005320 | arachidonate | 45.57 | 0.2 |
MOL005321 | Frutinone A | 65.9 | 0.34 |
MOL005344 | ginsenoside rh2 | 36.32 | 0.56 |
MOL005348 | Ginsenoside-Rh4_qt | 31.11 | 0.78 |
MOL005356 | Girinimbin | 61.22 | 0.31 |
MOL005357 | Gomisin B | 31.99 | 0.83 |
MOL005360 | malkangunin | 57.71 | 0.63 |
MOL005376 | Panaxadiol | 33.09 | 0.79 |
MOL005384 | suchilactone | 57.52 | 0.56 |
MOL005399 | alexandrin_qt | 36.91 | 0.75 |
MOL005401 | ginsenoside Rg5_qt | 39.56 | 0.79 |
MOL000787 | Fumarine | 59.26 | 0.83 |
1 | 孟焕新. 牙周病学[M]. 5版. 北京: 人民卫生出版社, 2020: 146-147. |
Meng HX. Periodontology[M]. 5th ed. Beijing: People’s Medical Publishing House, 2020: 146-147. | |
2 | Global oral health status report: towards universal heal-th coverage for oral health by 2030[R]. Geneva: World Health Organization, 2022: 37-40. |
3 | Figuero E, Han YW, Furuichi Y. Periodontal diseases and adverse pregnancy outcomes: mechanisms[J]. Periodontol 2000, 2020, 83(1): 175-188. |
4 | Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases[J]. Nat Rev Endocrinol, 2011, 7(12): 738-748. |
5 | Sanz M, Del Castillo AM, Jepsen S, et al. Periodontitis and cardiovascular diseases: consensus report[J]. J Clin Periodontol, 2020, 47(3): 268-288. |
6 | Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study[J]. Lancet Oncol, 2008, 9(6): 550-558. |
7 | Schmidlin PR, Fachinger P, Tini G, et al. Shared microbiome in gums and the lung in an outpatient population[J]. J Infect, 2015, 70(3): 255-263. |
8 | Jungbauer G, Stähli A, Zhu X, et al. Periodontal microorganisms and Alzheimer disease—A causative relationship[J]. Periodontol 2000, 2022, 89(1): 59-82. |
9 | Tsai CY, Tang CY, Tan TS, et al. Subgingival microbiota in individuals with severe chronic periodontitis[J]. J Microbiol Immunol Infect, 2018, 51(2): 226-234. |
10 | Slots J. Periodontitis: facts, fallacies and the future[J]. Periodontol 2000, 2017, 75(1): 7-23. |
11 | Graziani F, Karapetsa D, Alonso B, et al. Nonsurgical and surgical treatment of periodontitis: how many options for one disease[J]. Periodontol 2000, 2017, 75(1): 152-188. |
12 | Bhatavadekar NB, Williams RC. Modulation of the host inflammatory response in periodontal disease management: exciting new directions[J]. Int Dent J, 2009, 59(5): 305-308. |
13 | Shergis JL, Zhang AL, Zhou W, et al. Panax ginseng in randomised controlled trials: a systematic review[J]. Phy-tother Res, 2013, 27(7): 949-965. |
14 | Fan W, Huang Y, Zheng H, et al. Ginsenosides for the treatment of metabolic syndrome and cardiovascular di-seases: pharmacology and mechanisms[J]. Biomed Pharmacother, 2020, 132: 110915. |
15 | Qi HY, Li L, Ma H. Cellular stress response mechanisms as therapeutic targets of ginsenosides[J]. Med Res Rev, 2018, 38(2): 625-654. |
16 | Li X, Liu J, Zuo TT, et al. Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis[J]. Nat P-rod Rep, 2022, 39(4): 875-909. |
17 | Oh SJ, Oh Y, Ryu IW, et al. Protective properties of ginsenoside Rb3 against UV-B radiation-induced oxidative stress in HaCaT keratinocytes[J]. Biosci Biotechnol Biochem, 2016, 80(1): 95-103. |
18 | Xing JJ, Hou JG, Ma ZN, et al. Ginsenoside Rb3 provi-des protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated auto-phagy and inhibition of apoptosis in vitro and in vivo [J]. Cell Prolif, 2019, 52(4): e12627. |
19 | Liu X, Jiang Y, Fu W, et al. Combination of the ginseno-sides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats[J]. Int J Mol Med, 2020, 45(2): 519-531. |
20 | Sun M, Ji Y, Zhou S, et al. Ginsenoside Rb3 inhibits osteoclastogenesis via ERK/NF‑κB signaling pathway in vitro and in vivo [J]. Oral Dis, 2023, 29(8): 3460-3471. |
21 | Sun M, Ji Y, Li Z, et al. Ginsenoside Rb3 inhibits pro-inflammatory cytokines via MAPK/AKT/NF-κB pathways and attenuates rat alveolar bone resorption in response to Porphyromonas gingivalis LPS[J]. Molecules, 2020, 25(20): 4815. |
22 | 赵欢, 开国银, 韩冰. 基于网络药理学和分子对接的丹参饮抗结肠癌作用机制[J]. 中国药理学通报, 2022, 38(4): 598-605. |
Zhao H, Kai GY, Han B. Study of Danshen decoction on colon cancer based on network pharmacology and molecular docking[J]. Chin Pharmacol Bull, 2022, 38(4): 598-605. | |
23 | 宗阳, 丁美林, 贾可可, 等. 基于网络药理学和分子对接法探寻达原饮治疗新型冠状病毒肺炎(COVID-19)活性化合物的研究[J]. 中草药, 2020, 51(4): 836-844. |
Zong Y, Ding ML, Jia KK, et al. Exploring active compounds of Da-Yuan-Yin in treatment of COVID-19 based on network pharmacology and molecular docking method[J]. Chin Tradit Herbal Drugs, 2020, 51(4): 836-844. | |
24 | 唐萍, 唐芳婷, 王红, 等. 基于网络药理学及分子对接探讨人参治疗胃癌的作用机制[J]. 湖南中医杂志, 2023, 39(6): 162-169. |
Tang P, Tang FT, Wang H, et al. Mechanism of action of Panax ginseng in treatment of gastric cancer: a study based on network pharmacology and molecular docking[J]. Hunan J Tradit Chin Med, 2023, 39(6): 162-169. | |
25 | Chen W, Yao P, Vong CT, et al. Ginseng: a bibliometric analysis of 40-year journey of global clinical trials[J]. J Adv Res, 2020, 34: 187-197. |
26 | 刘丽, 李雅萍, 王娟, 等. 三七凝胶治疗牙周炎的初步研究[J]. 宁夏医学杂志, 2022, 44(12): 1074-1077. |
Liu L, Li YP, Wang J, et al. Preliminary study on the curative effect of panax notoginseng gel on periodontitis[J]. Ningxia Med J, 2022, 44(12): 1074-1077. | |
27 | 杨倩, 余占海, 杜建东, 等. 人参皂甙Rg-1对大鼠牙周组织中白介素6、骨钙素水平的影响[J]. 实用口腔医学杂志, 2009, 25(1): 22-25. |
Yang Q, Yu ZH, Du JD, et al. Effects of ginsenoside Rg-1 on the expressions of interleukin-6, bone gla protein in periodontal tissues in periodontitis rats[J]. J Pract Stomatol, 2009, 25(1): 22-25. | |
28 | Kim EN, Kim TY, Park EK, et al. Panax ginseng fruit has anti-inflammatory effect and induces ssteogenic differentiation by regulating Nrf2/HO-1 signaling pathway in vitro and in vivo models of periodontitis[J]. Antioxidants (Basel), 2020, 9(12): 1221. |
29 | Gölz L, Memmert S, Rath-Deschner B, et al. Hypoxia and P. gingivalis synergistically induce HIF-1 and NF-κB activation in PDL cells and periodontal diseases[J]. Mediators Inflamm, 2015, 2015: 438085. |
30 | Ng KT, Li JP, Ng KM, et al. Expression of hypoxia-inducible factor-1α in human periodontal tissue[J]. J Perio-dontol, 2011, 82(1): 136-141. |
31 | 唐宋, 张晓南. 牙周组织低氧环境与牙周炎发生发展的研究进展[J]. 同济大学学报(医学版), 2021, 42(2): 285-290. |
Tang S, Zhang XN. Relationship between hypoxic environment in periodontal tissue and the development of pe-riodontitis[J]. J Tongji Univ (Med Sci), 2021, 42(2): 285-290. | |
32 | Hirai K, Furusho H, Hirota K, et al. Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss[J]. Int J Oral Sci, 2018, 10(2): 12. |
33 | 施庆颜, 靳华, 蓝田, 等. 缺氧诱导因子1α在人慢性牙周炎牙龈组织中的表达[J]. 中国病理生理杂志, 2013, 29(9): 1668-1671. |
Shi QY, Jin H, Lan T, et al. Expression of hypoxia-inducible factor 1α in human gingival tissues with chronic periodontitis[J]. Chin J Pathophysiol, 2013, 29(9): 1668-1671. | |
34 | Wang C, Liu C, Liang C, et al. Role of berberine thermosensitive hydrogel in periodontitis via PI3K/AKT pathway in vitro [J]. Int J Mol Sci, 2023, 24(7): 6364. |
35 | Tian T, Chen L, Wang Z, et al. Sema3A drives alternative macrophage activation in the resolution of periodontitis via PI3K/AKT/mTOR signaling[J]. Inflammation, 2023, 46(3): 876-891. |
36 | Han Y, Wang X, Ma D, et al. Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pa-thway[J]. Drug Des Devel Ther, 2018, 12: 137-148. |
37 | 万美钰, 窦德强. 基于网络药理学探究人参、红参与黑参治疗气虚的药效物质基础与机制[J]. 人参研究, 2023, 35(3): 2-8. |
Wan MY, Dou DQ. Exploring the pharmacological substance basis and mechanism of ginseng, red ginseng, and black ginseng in treating qi deficiency based on network pharmacology[J]. Ginseng Res, 2023, 35(3): 2-8. | |
38 | Sczepanik FSC, Grossi ML, Casati M, et al. Periodon-titis is an inflammatory disease of oxidative stress: we should treat it that way[J]. Periodontol 2000, 2020, 84(1): 45-68. |
39 | Bullon P, Newman HN, Obesity Battino M., me-llitus diabetes, atherosclerosis and chronic periodontitis : a shared pathology via oxidative stress and mitochondrial dysfunction[J]. Periodontol 2000, 2014, 64(1): 139-153. |
40 | Han X, Zhao S, Song H, et al. Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: implications in Parkinson’s disease[J]. Redox Biol, 2021, 41: 101911. |
41 | Yang L, Gao Y, Bajpai VK, et al. Advance toward isolation, extraction, metabolism and health benefits of kaem-pferol, a major dietary flavonoid with future perspectives[J]. Crit Rev Food Sci Nutr, 2023, 63(16): 2773-2789. |
42 | Chen M, Xiao J, El-Seedi HR, et al. Kaempferol and atherosclerosis: from mechanism to medicine[J]. Crit Rev Food Sci Nutr, 2022. doi: 10.1080/10408398.2022.21212-61 . |
43 | Fossier L, Panel M, Butruille L, et al. Enhanced mitochondrial calcium uptake suppresses atrial fibrillation associated with metabolic syndrome[J]. J Am Coll Cardiol, 2022, 80(23): 2205-2219. |
44 | Xie C, Zhuang XX, Niu Z, et al. Amelioration of Alzheimer’s disease pathology by mitophagy inducers i-dentified via machine learning and a cross-species workflow[J]. Nat Biomed Eng, 2022, 6(1): 76-93. |
45 | Zhao J, Ling L, Zhu W, et al. M1/M2 re-polarization of kaempferol biomimetic NPs in anti-inflammatory therapy of atherosclerosis[J]. J Control Release, 2023, 353: 1068-1083. |
46 | Wang S, Shi X, Li J, et al. A small molecule selected from a DNA-encoded library of natural products that binds to TNF‑α and attenuates inflammation in vivo [J]. Adv Sci (Weinh), 2022, 9(21): 2201258. |
47 | Behl T, Mehta K, Sehgal A, et al. Exploring the role of polyphenols in rheumatoid arthritis[J]. Crit Rev Food Sci Nutr, 2022, 62(19): 5372-5393. |
48 | Han X, Sun S, Sun Y, et al. Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease[J]. Autophagy, 2019, 15(11): 1860-1881. |
49 | Yang EJ, Kim GS, Jun M, et al. Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells[J]. Food Funct, 2014, 5(7): 1395-1402. |
50 | Liu Z, Yao X, Sun B, et al. Pretreatment with kaempfe-rol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury[J]. Free Radic Biol Med, 2021, 168: 142-154. |
51 | Xiao X, Hu Q, Deng X, et al. Old wine in new bottles: kaempferol is a promising agent for treating the trilogy of liver diseases[J]. Pharmacol Res, 2022, 175: 106005. |
52 | Kim MJ, Song YR, Kim YE, et al. Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase[J]. Free Radic Biol Med, 2023, 208: 630-642. |
53 | Wang H, Wang Z, Zhang Z, et al. β-Sitosterol as a promising anticancer agent for chemoprevention and chemotherapy: mechanisms of action and future prospects[J]. Adv Nutr, 2023, 14(5): 1085-1110. |
54 | Khan Z, Nath N, Rauf A, et al. Multifunctional roles and pharmacological potential of β-sitosterol: emerging evidence toward clinical applications[J]. Chem Biol Inte-ract, 2022, 365: 110117. |
55 | Zhang F, Liu Z, He X, et al. β-sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway[J]. Drug Deliv, 2020, 27(1): 1329-1341. |
56 | Babu S, Jayaraman S. An update on β-sitosterol: a potential herbal nutraceutical for diabetic management[J]. Bio-med Pharmacother, 2020, 131: 110702. |
57 | Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy[J]. Nat Rev Drug Discov, 2016, 15(6): 385-403. |
58 | Han Y, You X, Xing W, et al. Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts[J]. Bone Res, 2018, 6: 16. |
59 | Ferrara N. Vascular endothelial growth factor: basic science and clinical progress[J]. Endocr Rev, 2004, 25(4): 581-611. |
60 | Huang Q, Li F, Liu X, et al. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy[J]. Nat Med, 2011, 17(7): 860-866. |
61 | Nozaki K, Maltez VI, Rayamajhi M, et al. Caspase-7 activates ASM to repair gasdermin and perforin pores[J]. Nature, 2022, 606(7916): 960-967. |
[1] | Ma Haonan, Li Qiong, Shang Yaqi, Xin Xirui, Liu Xinchan, Wu Zhou, Yu Weixian. Impact of circadian clock protein Bmal1 on experimentally-induced periodontitis-associated renal injury [J]. West China Journal of Stomatology, 2024, 42(2): 163-171. |
[2] | Ye Changchang, Yang He, Huang Ping. Application of intentional replantation in advanced periodontitis involving teeth preservation [J]. West China Journal of Stomatology, 2024, 42(1): 12-18. |
[3] | Wang Jun.. Vital pulp therapy of permanent teeth with irreversible pulpitis [J]. West China Journal of Stomatology, 2023, 41(6): 622-627. |
[4] | Wang Qintao, Ma Zhiwei, Wang Jinjin.. Personal understanding of the extraction or rescue on severe periodontitis teeth [J]. West China Journal of Stomatology, 2023, 41(6): 635-640. |
[5] | Zhang Yanbiao, Wei Meirong, Xia Tianyong, Yin Wenting, Mao Shumei. Association between serum Galectin-3 and periodontitis in patients with type 2 diabetes mellitus [J]. West China Journal of Stomatology, 2023, 41(6): 653-661. |
[6] | Cai Hongxuan, Wang Zheng’an, Zhang Zan, Dai Jingyi, Si Weixing, Fu Qiya, Yang Jingwen, Tian Yaguang. Morinda officinalis polysaccharides inhibit the expression and activity of NOD-like receptor thermal protein domain associated protein 3 in inflammatory periodontal ligament cells by upregulating silent information regulator sirtuin 1 [J]. West China Journal of Stomatology, 2023, 41(6): 662-670. |
[7] | Jiang Jianhong, Shi Xinglian, He Quanmin, Gao Li, Yang Kun, Wang Taiping, Li Zhezhen, Liu Mei. Correlation between health literacy and life quality in elderly patients with chronic periodontitis [J]. West China Journal of Stomatology, 2023, 41(6): 694-700. |
[8] | Lin Li, Li Zhaorong, Jin Yining, Yin Shou-cheng.. Treatment strategies for periodontitis patients with systemic disease [J]. West China Journal of Stomatology, 2023, 41(5): 502-511. |
[9] | Zhang Chen, Hou Zhenzhen, Zong Yingrui.. Exploratory research on the probable shared molecular mechanism and transcription factors between chronic periodontitis and chronic obstructive pulmonary disease [J]. West China Journal of Stomatology, 2023, 41(5): 533-540. |
[10] | Yang Jingmei, Zhou Ziliang, Wu Yafei, Nie Min. Study on the mechanism of curcumin in the treatment of periodontitis through network pharmacology and mole-cular docking [J]. West China Journal of Stomatology, 2023, 41(2): 157-164. |
[11] | You Ziying, Wu Yanlin, Sun Yimin, Wang Zhenming, Ye Ling.. Application of gelatin methacryloyl/minocycline-chitosan-nanoparticles composite hydrogel for the treatment of periodontitis [J]. West China Journal of Stomatology, 2023, 41(1): 11-20. |
[12] | Cao Niuben, Liu Xiaomeng, Deng Yu, Liu Xinchan, Xin Yu, Yu Weixian. Reactive oxygen species/c-Jun N-terminal kinase/nuclear factor kappa-B signaling molecules are involved in pe-riodontitis-induced liver injury by regulating apoptosis [J]. West China Journal of Stomatology, 2022, 40(5): 532-540. |
[13] | Tao Yufei, He Mengna, Hu Hongyan, Gao Ziwen, Huang Ziang, Li Hui, Li Yuqing, Li Xiaoshu. Correlation study of periodontitis with cognitive impairment [J]. West China Journal of Stomatology, 2022, 40(5): 549-553. |
[14] | Qian Jun, Ma Rui, Qu Yan, Deng Shaochun, Duan Yao, Zuo Feifei, Wang Yajie, Wu Yuwei. Use and performance of artificial intelligence applications in the diagnosis of chronic apical periodontitis based on cone beam computed tomography imaging [J]. West China Journal of Stomatology, 2022, 40(5): 576-581. |
[15] | Dai Zhenning, Zheng Weihan, Li Shiyu. Receptor activator of nuclear factor-κB ligand and tumor necrosis factor-α promotes osteoclast differentiation through the exosomes of inflammatory periodontal ligament stem cells [J]. West China Journal of Stomatology, 2022, 40(4): 377-385. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||